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    Bend6 BEN domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363212, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bend6provided by RGD
    Official Full Name
    BEN domain containing 6provided by RGD
    Primary source
    RGD:1310392
    See related
    EnsemblRapid:ENSRNOG00000052376 AllianceGenome:RGD:1310392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310392
    Summary
    Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Predicted to be active in nucleus. Orthologous to human BEND6 (BEN domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 487.6) and Lung (RPKM 27.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bend6 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (43576982..43631437, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36081033..36135309, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (38297253..38351312)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 5 Neighboring gene zinc finger protein 451 Neighboring gene ribosomal protein S18, pseudogene 7 Neighboring gene dystonin Neighboring gene uncharacterized LOC102551615 Neighboring gene uncharacterized LOC134480566

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Dai Q, et al. Genes Dev, 2015 Jan 1. PMID 25561495, Free PMC Article
    2. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Dai Q, et al. Development, 2013 May. PMID 23571214, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BEN domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393774.1 → NP_001380703.1  BEN domain-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K8T8, A6IN97
      Related
      ENSRNOP00000072521.3, ENSRNOT00000088824.3
      Conserved Domains (2) summary
      smart01025
      Location:190 → 267
      BEN; The BEN domain is found in diverse animal proteins
      NF033175
      Location:46 → 95
      fuso_auto_Nterm; autotransporter-associated N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      43576982..43631437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267364.1 → XP_063123434.1  BEN domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8T8

    RNA

    1. XR_010054613.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108792.2: Suppressed sequence

      Description
      NM_001108792.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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