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    Arl6 ARF like GTPase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363760, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arl6provided by RGD
    Official Full Name
    ARF like GTPase 6provided by RGD
    Primary source
    RGD:1305535
    See related
    EnsemblRapid:ENSRNOG00000001689 AllianceGenome:RGD:1305535
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; fat cell differentiation; and protein localization to non-motile cilium. Predicted to act upstream of or within several processes, including protein transport from ciliary membrane to plasma membrane; regulation of smoothened signaling pathway; and retina layer formation. Predicted to be located in several cellular components, including cilium; cytosol; and microtubule cytoskeleton. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 89.5), Kidney (RPKM 83.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arl6 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (54180271..54207136)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (40711878..40738254)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (42858476..42884324)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene Eph receptor A6 Neighboring gene uncharacterized LOC134480984 Neighboring gene U7 small nuclear RNA Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 1 Neighboring gene ribosomal oxygenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. Wiens CJ, et al. J Biol Chem, 2010 May 21. PMID 20207729, Free PMC Article
    2. Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform. Pretorius PR, et al. PLoS Genet, 2010 Mar 19. PMID 20333246, Free PMC Article
    3. Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Su X, et al. Hum Mol Genet, 2014 Oct 15. PMID 24939912, Free PMC Article
    4. Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Fan Y, et al. Nat Genet, 2004 Sep. PMID 15314642
    5. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. Ingley E, et al. FEBS Lett, 1999 Oct 1. PMID 10508919

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport from ciliary membrane to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 6
    Names
    ADP-ribosylation factor like GTPase 6
    ADP-ribosylation factor-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108842.1 → NP_001102312.1  ADP-ribosylation factor-like protein 6

      Status: PROVISIONAL

      Source sequence(s)
      CH473967
      UniProtKB/TrEMBL
      A0A8J8YB99, A6IQI5
      Conserved Domains (1) summary
      cd04157
      Location:19 → 178
      Arl6; Arf-like 6 (Arl6) GTPase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      54180271..54207136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248193.5 → XP_006248255.1  ADP-ribosylation factor-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACB6, A0A8J8YB99, B1WC73, F7F983
      Related
      ENSRNOP00000091133.1, ENSRNOT00000110067.2
      Conserved Domains (1) summary
      cd04157
      Location:19 → 180
      Arl6; Arf-like 6 (Arl6) GTPase
    Nucleotide Protein Strain
    Heading Accession and Version

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