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    NMRAL2P NmrA like redox sensor 2, pseudogene [ Homo sapiens (human) ]

    Gene ID: 344887, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NMRAL2Pprovided by HGNC
    Official Full Name
    NmrA like redox sensor 2, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:52332
    See related
    Ensembl:ENSG00000290862 AllianceGenome:HGNC:52332
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NMRAL1P1
    Expression
    Biased expression in skin (RPKM 5.5), colon (RPKM 2.2) and 7 other tissues See more
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    Genomic context

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    See NMRAL2P in Genome Data Viewer
    Location:
    3q27.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (185959943..185980877)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188775734..188796678)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185677732..185698666)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene insulin like growth factor 2 mRNA binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185487094-185487594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185487595-185488095 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185491440-185492292 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:185496875-185497772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185497860-185498360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185501879-185502772 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185504559-185505450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185507237-185508130 Neighboring gene VISTA enhancer hs1976 Neighboring gene microRNA 548aq Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185516757-185517258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185517259-185517758 Neighboring gene NANOG hESC enhancer GRCh37_chr3:185520396-185520897 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:185525354-185525896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185540833-185541696 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185542636-185542866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14978 Neighboring gene Sharpr-MPRA regulatory region 6530 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185623478-185623669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185655136-185655863 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185666824-185667766 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185667767-185668709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185670624-185671147 Neighboring gene transformer 2 beta homolog Neighboring gene Sharpr-MPRA regulatory region 2251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185701333-185701854 Neighboring gene uncharacterized LOC124909470 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185795356-185795551 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:185815375-185815888 Neighboring gene ETS variant transcription factor 5 Neighboring gene ETV5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20931 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:185826419-185827397 Neighboring gene uncharacterized LOC105374257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA Loc344887 is a potential prognostic biomarker in non-small cell lung cancer. Wu B, et al. Eur Rev Med Pharmacol Sci, 2017 Oct. PMID 28975987
    2. The NmrA-like family domain containing 1 pseudogene Loc344887 is amplified in gallbladder cancer and promotes epithelial-mesenchymal transition. Wu XC, et al. Chem Biol Drug Des, 2017 Sep. PMID 28245089
    3. A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. Johnson GS, et al. Mol Nutr Food Res, 2017 Apr. PMID 27860235, Free PMC Article
    4. The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis. Liu P, et al. Redox Biol, 2021 Jan. PMID 33126057, Free PMC Article
    5. Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression. Feng H, et al. Yonsei Med J, 2020 Jun. PMID 32469171, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in head and neck tumors by interacting with the ENO1 protein and promoting GPX2 transcription.
      Title: Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in head and neck tumors by interacting with the ENO1 protein and promoting GPX2 transcription.
    2. NMRAL2P activation suppresses ACOT7 expression in gastric cancer.
      Title: Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
    EBI GWAS Catalog

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • NmrA like redox sensor 1 pseudogene 1
    • NmrA-like family domain containing 1 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_151491.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108671, BX640843, DB012852, DB015100
      Related
      ENST00000423298.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      185959943..185980877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      188775734..188796678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033752.2: Suppressed sequence

      Description
      NR_033752.2: This RefSeq was removed because there is currently insufficient evidence for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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