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    SLPI secretory leukocyte peptidase inhibitor [ Homo sapiens (human) ]

    Gene ID: 6590, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLPIprovided by HGNC
    Official Full Name
    secretory leukocyte peptidase inhibitorprovided by HGNC
    Primary source
    HGNC:HGNC:11092
    See related
    Ensembl:ENSG00000124107 MIM:107285; AllianceGenome:HGNC:11092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I
    Summary
    This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in salivary gland (RPKM 1077.5), lung (RPKM 390.4) and 4 other tissues See more
    Orthologs
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    Genomic context

    See SLPI in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45252239..45254564, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46988133..46990454, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43880880..43883205, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372630 Neighboring gene semenogelin 2 Neighboring gene uncharacterized LOC124904913 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12955 Neighboring gene matrilin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12956 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17946 Neighboring gene tRNA-Val (anticodon CAC) 14-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The expression and production of secretory leukocyte protease inhibitor (SLPI), a 12-kDa mucosal antiviral protein, can be stimulated in oral epithelial cells through interactions with HIV-1 gp120 PubMed
    retropepsin gag-pol Secretory levels of secretory leukocyte peptidase inhibitor (SLPI) from HIV-1 infected patients is enhanced in saliva PubMed
    gag-pol Human secretory leukocyte protease inhibitor (hSLPI) inhibits HIV-1 infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables endopeptidase inhibitor activity PubMed 
    enables enzyme binding PubMed 
    enables mRNA binding PubMed 
    enables protein binding PubMed 
    enables serine-type endopeptidase inhibitor activity  
    enables serine-type endopeptidase inhibitor activity PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial humoral response  
    involved_in antibacterial humoral response PubMed 
    involved_in antibacterial humoral response  
    involved_in immune response  
    involved_in innate immune response  
    involved_in innate immune response  
    involved_in modulation of process of another organism PubMed 
    involved_in negative regulation of protein binding PubMed 
    involved_in negative regulation of viral genome replication PubMed 
    involved_in response to lipopolysaccharide  

    General protein information

    Preferred Names
    antileukoproteinase
    Names
    HUSI-1
    WAP four-disulfide core domain protein 4
    mucus proteinase inhibitor
    protease inhibitor WAP4
    secretory leukocyte protease inhibitor (antileukoproteinase)
    seminal proteinase inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028137.1 RefSeqGene

      Range
      5002..7327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003064.4 → NP_003055.1  antileukoproteinase precursor

      See identical proteins and their annotated locations for NP_003055.1

      Status: REVIEWED

      Source sequence(s)
      BC020708
      Consensus CDS
      CCDS13347.1
      UniProtKB/Swiss-Prot
      B2R5H8, P03973, P07757
      Related
      ENSP00000342082.2, ENST00000338380.2
      Conserved Domains (2) summary
      smart00217
      Location:85 → 130
      WAP; Four-disulfide core domains
      pfam00095
      Location:31 → 73
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      45252239..45254564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      46988133..46990454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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