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    ANAPC2 anaphase promoting complex subunit 2 [ Homo sapiens (human) ]

    Gene ID: 29882, updated on 3-Dec-2024

    Summary

    Official Symbol
    ANAPC2provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:19989
    See related
    Ensembl:ENSG00000176248 MIM:606946; AllianceGenome:HGNC:19989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC2
    Summary
    A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 16.5), spleen (RPKM 12.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ANAPC2 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137174784..137188560, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149412464..149426223, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140069236..140083012, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20587 Neighboring gene leucine rich repeat containing 26 Neighboring gene microRNA 3621 Neighboring gene uncharacterized LOC124902315 Neighboring gene transmembrane protein 210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140069251-140070084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20588 Neighboring gene SS nuclear autoantigen 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140088338-140089216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:140089217-140090094 Neighboring gene taperin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20590

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of anaphase promoting complex subunit 2 (ANAPC2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
    Knockdown of anaphase promoting complex subunit 2 (ANAPC2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with anaphase promoting complex subunit 2 (ANAPC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with anaphase promoting complex subunit 2 (ANAPC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 2
    Names
    cyclosome subunit 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013366.4NP_037498.1  anaphase-promoting complex subunit 2

      See identical proteins and their annotated locations for NP_037498.1

      Status: REVIEWED

      Source sequence(s)
      BC032503, BM925063
      Consensus CDS
      CCDS7033.1
      UniProtKB/Swiss-Prot
      Q5VSG1, Q96DG5, Q96GG4, Q9P2E1, Q9UJX6
      Related
      ENSP00000314004.2, ENST00000323927.3
      Conserved Domains (2) summary
      smart01013
      Location:757817
      APC2; Anaphase promoting complex (APC) subunit 2
      pfam00888
      Location:512694
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      137174784..137188560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423275.1XP_047279231.1  anaphase-promoting complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      B4DGH7
    2. XM_047423274.1XP_047279230.1  anaphase-promoting complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      B4DGH7
    3. XM_047423276.1XP_047279232.1  anaphase-promoting complex subunit 2 isoform X3

      UniProtKB/TrEMBL
      B4DGH7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      149412464..149426223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362821.1XP_054218796.1  anaphase-promoting complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      B4DGH7
    2. XM_054362820.1XP_054218795.1  anaphase-promoting complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      B4DGH7
    3. XM_054362822.1XP_054218797.1  anaphase-promoting complex subunit 2 isoform X3

      UniProtKB/TrEMBL
      B4DGH7