U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RNF183 ring finger protein 183 [ Homo sapiens (human) ]

    Gene ID: 138065, updated on 4-Dec-2024

    Summary

    Official Symbol
    RNF183provided by HGNC
    Official Full Name
    ring finger protein 183provided by HGNC
    Primary source
    HGNC:HGNC:28721
    See related
    Ensembl:ENSG00000165188 MIM:621029; AllianceGenome:HGNC:28721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables ubiquitin protein ligase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein ubiquitination; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in gall bladder (RPKM 1.5), kidney (RPKM 1.3) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RNF183 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113297093..113303376, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125495894..125502177, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116059373..116065656, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116036963-116037818 Neighboring gene cell division cycle 26 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106320 Neighboring gene pre-mRNA splicing tri-snRNP complex factor PRPF4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106329 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106330 Neighboring gene WD repeat domain 31 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20201 Neighboring gene B-box and SPRY domain containing Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116131698-116132198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:116132199-116132699

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC4734, FLJ31197

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cis-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF183
    Names
    probable E3 ubiquitin-protein ligase RNF183
    NP_001358163.1
    NP_001358164.1
    NP_001358165.1
    NP_001358166.1
    NP_001374497.1
    NP_001374498.1
    NP_659488.2
    XP_024303178.1
    XP_024303179.1
    XP_024303180.1
    XP_047278717.1
    XP_047278718.1
    XP_047278719.1
    XP_047278720.1
    XP_047278721.1
    XP_054217938.1
    XP_054217939.1
    XP_054217940.1
    XP_054217941.1
    XP_054217942.1
    XP_054217943.1
    XP_054217944.1
    XP_054217945.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371234.1NP_001358163.1  E3 ubiquitin-protein ligase RNF183

      Status: VALIDATED

      Source sequence(s)
      AL449305
      Consensus CDS
      CCDS43866.1
      UniProtKB/Swiss-Prot
      Q96D59
      Related
      ENSP00000420740.1, ENST00000416588.2
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    2. NM_001371235.1NP_001358164.1  E3 ubiquitin-protein ligase RNF183

      Status: VALIDATED

      Source sequence(s)
      AL449305
      Consensus CDS
      CCDS43866.1
      UniProtKB/Swiss-Prot
      Q96D59
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    3. NM_001371236.1NP_001358165.1  E3 ubiquitin-protein ligase RNF183

      Status: VALIDATED

      Source sequence(s)
      AL449305
      Consensus CDS
      CCDS43866.1
      UniProtKB/Swiss-Prot
      Q96D59
      Related
      ENSP00000417943.1, ENST00000297894.5
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    4. NM_001371237.1NP_001358166.1  E3 ubiquitin-protein ligase RNF183

      Status: VALIDATED

      Source sequence(s)
      AL449305
      Consensus CDS
      CCDS43866.1
      UniProtKB/Swiss-Prot
      Q96D59
      Related
      ENSP00000508293.1, ENST00000489339.2
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    5. NM_001387568.1NP_001374497.1  E3 ubiquitin-protein ligase RNF183

      Status: VALIDATED

      Source sequence(s)
      AL449305
      Consensus CDS
      CCDS43866.1
      UniProtKB/Swiss-Prot
      Q96D59
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    6. NM_001387569.1NP_001374498.1  E3 ubiquitin-protein ligase RNF183

      Status: VALIDATED

      Source sequence(s)
      AL449305
      Consensus CDS
      CCDS43866.1
      UniProtKB/Swiss-Prot
      Q96D59
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    7. NM_145051.5NP_659488.2  E3 ubiquitin-protein ligase RNF183

      See identical proteins and their annotated locations for NP_659488.2

      Status: VALIDATED

      Source sequence(s)
      AL449305
      Consensus CDS
      CCDS43866.1
      UniProtKB/Swiss-Prot
      Q96D59
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      113297093..113303376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422765.1XP_047278721.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
      Related
      ENSP00000419454.1, ENST00000478815.1
    2. XM_024447412.2XP_024303180.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    3. XM_024447411.2XP_024303179.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins
    4. XM_047422763.1XP_047278719.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    5. XM_047422764.1XP_047278720.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    6. XM_047422762.1XP_047278718.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    7. XM_047422761.1XP_047278717.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    8. XM_024447410.1XP_024303178.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
      Conserved Domains (1) summary
      cd16556
      Location:1263
      RING-HC_RNF183_like; RING finger, HC subclass, found in RING finger protein RNF183, RNF223 and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      125495894..125502177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361969.1XP_054217944.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    2. XM_054361968.1XP_054217943.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    3. XM_054361970.1XP_054217945.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    4. XM_054361965.1XP_054217940.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    5. XM_054361966.1XP_054217941.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    6. XM_054361964.1XP_054217939.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    7. XM_054361963.1XP_054217938.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59
    8. XM_054361967.1XP_054217942.1  E3 ubiquitin-protein ligase RNF183 isoform X1

      UniProtKB/Swiss-Prot
      Q96D59