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    GABBR1 gamma-aminobutyric acid type B receptor subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2550, updated on 3-Dec-2024

    Summary

    Official Symbol
    GABBR1provided by HGNC
    Official Full Name
    gamma-aminobutyric acid type B receptor subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4070
    See related
    Ensembl:ENSG00000204681 MIM:603540; AllianceGenome:HGNC:4070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GB1; NEDLC; GPRC3A; GABABR1; GABBR1-3
    Summary
    This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in brain (RPKM 72.0), spleen (RPKM 14.7) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GABBR1 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (29602238..29633183, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (29476949..29507887, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29570015..29600960, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13a pseudogene Neighboring gene olfactory receptor family 2 subfamily H member 2 Neighboring gene NANOG hESC enhancer GRCh37_chr6:29562576-29563083 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29589456-29590006 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29590007-29590556 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29592149-29592734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29596552-29597357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29598769-29599270 Neighboring gene SUMO2 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:29610193-29610692 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:29616349-29616969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:29622853-29623353 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:29627633-29628069 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29628451-29629365 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29629366-29630280 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:29630281-29631194 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634045-29634654 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:29634655-29635264 Neighboring gene myelin oligodendrocyte glycoprotein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with language delay and variable cognitive abnormalities
    MedGen: C5882689 OMIM: 620502 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ92613

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of G protein-coupled GABA receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of G protein-coupled receptor heterodimeric complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    gamma-aminobutyric acid type B receptor subunit 1
    Names
    GABA-B receptor, R1 subunit
    gamma-aminobutyric acid (GABA) B receptor, 1
    seven transmembrane helix receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029101.1 RefSeqGene

      Range
      5003..35948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001319053.2NP_001305982.1  gamma-aminobutyric acid type B receptor subunit 1 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon compared to variant 1. It encodes isoform k which has a shorter N-terminus than isoform a.
      Source sequence(s)
      AB208790, AJ225028, AL539611, AL645936
      UniProtKB/TrEMBL
      Q59HG8
      Conserved Domains (3) summary
      cd15291
      Location:413685
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam10211
      Location:708750
      Ax_dynein_light; Axonemal dynein light chain
      cd06366
      Location:2393
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    2. NM_001470.4NP_001461.1  gamma-aminobutyric acid type B receptor subunit 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001461.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB208790, AJ225028, AL539611, AL645936
      Consensus CDS
      CCDS4663.1
      UniProtKB/Swiss-Prot
      B0UXY7, O95375, O95468, O95975, O96022, Q5STL4, Q5SUJ8, Q5SUL3, Q71SG6, Q86W60, Q9UBS5, Q9UQQ0
      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R0, A0A1U9X7R1
      Related
      ENSP00000366233.4, ENST00000377034.9
      Conserved Domains (4) summary
      cd00033
      Location:106158
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd15291
      Location:590862
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam10211
      Location:885927
      Ax_dynein_light; Axonemal dynein light chain
      cd06366
      Location:171570
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    3. NM_021903.3NP_068703.1  gamma-aminobutyric acid type B receptor subunit 1 isoform b precursor

      See identical proteins and their annotated locations for NP_068703.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks several exons in the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. It encodes isoform b which has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AJ225028, BC041332, BC042598, DA112662
      Consensus CDS
      CCDS4665.1
      UniProtKB/TrEMBL
      Q53EM0, Q5SUJ9, Q8IW08
      Related
      ENSP00000366211.4, ENST00000377012.9
      Conserved Domains (5) summary
      cd06366
      Location:54446
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:486740
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:70426
      ANF_receptor; Receptor family ligand binding region
      pfam10211
      Location:768810
      Ax_dynein_light; Axonemal dynein light chain
      pfam16643
      Location:805829
      cNMPbd_u2; Unstructured region on cNMP-binding protein
    4. NM_021904.4NP_068704.2  gamma-aminobutyric acid type B receptor subunit 1 isoform c precursor

      See identical proteins and their annotated locations for NP_068704.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. It encodes isoform c which is shorter than isoform a.
      Source sequence(s)
      AB208790, AJ012187, AJ225028, AL539611, AL645936
      Consensus CDS
      CCDS4664.1
      UniProtKB/TrEMBL
      A0A140T9S4
      Related
      ENSP00000366215.4, ENST00000377016.8
      Conserved Domains (3) summary
      cd15291
      Location:528800
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam10211
      Location:823865
      Ax_dynein_light; Axonemal dynein light chain
      cd06366
      Location:109508
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      29602238..29633183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005248982.3XP_005249039.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_005249039.1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342
      Related
      ENSP00000417332.2, ENST00000476670.3
      Conserved Domains (3) summary
      cd15291
      Location:595867
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06366
      Location:176575
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00084
      Location:112162
      Sushi; Sushi repeat (SCR repeat)
    2. XM_006715047.5XP_006715110.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      See identical proteins and their annotated locations for XP_006715110.1

      UniProtKB/TrEMBL
      A0A140T9S4
      Conserved Domains (3) summary
      cd15291
      Location:533805
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam10211
      Location:828870
      Ax_dynein_light; Axonemal dynein light chain
      cd06366
      Location:114513
      PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    3. XM_011514453.4XP_011512755.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      See identical proteins and their annotated locations for XP_011512755.1

      UniProtKB/TrEMBL
      A0A140T9S4
      Conserved Domains (5) summary
      cd06366
      Location:107499
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:539793
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:123479
      ANF_receptor; Receptor family ligand binding region
      pfam10211
      Location:821863
      Ax_dynein_light; Axonemal dynein light chain
      pfam16643
      Location:858882
      cNMPbd_u2; Unstructured region on cNMP-binding protein
    4. XM_024446392.2XP_024302160.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
      Conserved Domains (3) summary
      cd06366
      Location:37380
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam10211
      Location:699744
      Ax_dynein_light; Axonemal dynein light chain
      cd15291
      Location:407679
      7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
    5. XM_047418591.1XP_047274547.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    6. XM_011514455.2XP_011512757.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      See identical proteins and their annotated locations for XP_011512757.1

      UniProtKB/TrEMBL
      A0A140TA42
      Conserved Domains (4) summary
      cd06366
      Location:176568
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:608677
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam00084
      Location:112162
      Sushi; Sushi repeat (SCR repeat)
      pfam01094
      Location:192548
      ANF_receptor; Receptor family ligand binding region
    7. XM_047418592.1XP_047274548.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X7

      UniProtKB/TrEMBL
      A0A140TA42
    8. XM_047418593.1XP_047274549.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42
      Related
      ENSP00000419061.1, ENST00000494877.5

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      867963..898900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328454.1XP_054184429.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342
    2. XM_054328456.1XP_054184431.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A140T9S4
    3. XM_054328455.1XP_054184430.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A140T9S4
    4. XM_054328458.1XP_054184433.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
    5. XM_054328457.1XP_054184432.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    6. XM_054328459.1XP_054184434.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TA42
    7. XM_054328460.1XP_054184435.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42

    RNA

    1. XR_008485589.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1088718..1119664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329751.1XP_054185726.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342
    2. XM_054329752.1XP_054185727.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A140T9S4
    3. XM_054329753.1XP_054185728.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A140T9S4
    4. XM_054329755.1XP_054185730.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
    5. XM_054329754.1XP_054185729.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    6. XM_054329756.1XP_054185731.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TA42
    7. XM_054329757.1XP_054185732.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X7

      UniProtKB/TrEMBL
      A0A140TA42
    8. XM_054329758.1XP_054185733.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      867787..898733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330243.1XP_054186218.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342
    2. XM_054330244.1XP_054186219.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A140T9S4
    3. XM_054330245.1XP_054186220.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A140T9S4
    4. XM_054330247.1XP_054186222.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
    5. XM_054330246.1XP_054186221.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    6. XM_054330248.1XP_054186223.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TA42
    7. XM_054330249.1XP_054186224.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X7

      UniProtKB/TrEMBL
      A0A140TA42
    8. XM_054330250.1XP_054186225.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      867419..898332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330538.1XP_054186513.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X10

      UniProtKB/TrEMBL
      Q59HG8
    2. XM_054330535.1XP_054186510.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2JKF9, A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1
    3. XM_054330534.1XP_054186509.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1
    4. XM_054330537.1XP_054186512.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A140T9S4
    5. XM_054330536.1XP_054186511.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A140T9S4
    6. XM_054330540.1XP_054186515.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
    7. XM_054330539.1XP_054186514.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    8. XM_054330541.1XP_054186516.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TA42
    9. XM_054330542.1XP_054186517.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42

    RNA

    1. XR_008485698.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      867633..898576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330786.1XP_054186761.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342
    2. XM_054330787.1XP_054186762.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A140T9S4
    3. XM_054330788.1XP_054186763.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A140T9S4
    4. XM_054330790.1XP_054186765.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
    5. XM_054330789.1XP_054186764.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    6. XM_054330791.1XP_054186766.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TA42
    7. XM_054330792.1XP_054186767.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X7

      UniProtKB/TrEMBL
      A0A140TA42
    8. XM_054330793.1XP_054186768.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      867750..898696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331023.1XP_054186998.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342
    2. XM_054331024.1XP_054186999.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A140T9S4
    3. XM_054331025.1XP_054187000.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A140T9S4
    4. XM_054331027.1XP_054187002.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
    5. XM_054331026.1XP_054187001.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    6. XM_054331028.1XP_054187003.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TA42
    7. XM_054331029.1XP_054187004.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X7

      UniProtKB/TrEMBL
      A0A140TA42
    8. XM_054331030.1XP_054187005.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      941945..942223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      29476949..29507887 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355056.1XP_054211031.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342
    2. XM_054355058.1XP_054211033.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A140T9S4
    3. XM_054355057.1XP_054211032.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A140T9S4
    4. XM_054355060.1XP_054211035.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q59HG8
    5. XM_054355059.1XP_054211034.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X4

      UniProtKB/TrEMBL
      Q59HG8
    6. XM_054355061.1XP_054211036.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X6

      UniProtKB/TrEMBL
      A0A140TA42
    7. XM_054355062.1XP_054211037.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X7

      UniProtKB/TrEMBL
      A0A140TA42
    8. XM_054355063.1XP_054211038.1  gamma-aminobutyric acid type B receptor subunit 1 isoform X8

      UniProtKB/TrEMBL
      A0A140TA42

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021905.2: Suppressed sequence

      Description
      NM_021905.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.