CHAD chondroadherin [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHADprovided by HGNC
Official Full Name: chondroadherinprovided by HGNC
Primary source: HGNC:HGNC:1909
See related: Ensembl:ENSG00000136457 MIM:602178; AllianceGenome:HGNC:1909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SLRR4A
Summary: Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [provided by RefSeq, Jul 2008]
Expression: Broad expression in small intestine (RPKM 4.5), liver (RPKM 4.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (50464496..50468880, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (51331492..51338062, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (48541857..48546241, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structures at ~2.2A resolution of human fibromodulin and chondroadherin.
Title: Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.
number of cells adhering via their beta(1) integrin receptor to collagen type II or chondroadherin was profoundly and rapidly enhanced by the addition of the heparin-binding peptide
Title: The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains.
chondroadherin interaction with cells may be central for maintaining the adult chondrocyte phenotype and cartilage homeostasis.
Title: Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment.
Changes in CHAD abundance or structure could be associated with the pathologic changes occurring in the scoliotic IVD.
Title: Variation in chondroadherin abundance and fragmentation in the human scoliotic disc.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G13356 (e-PCR)
- UniSTS:44736

CHAD_4562 (e-PCR)
- UniSTS:462811

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bone development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bone trabecula formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chondroadherin

Names: cartilage leucine-rich protein; chondroadherin proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001267.3 → NP_001258.2 chondroadherin precursor

See identical proteins and their annotated locations for NP_001258.2

Status: REVIEWED

Source sequence(s)

AC021491, BC036360, BC073974

Consensus CDS

CCDS11568.1

UniProtKB/Swiss-Prot

A8K812, O15335, Q6GTU0, Q96RJ5

Related

ENSP00000423812.1, ENST00000508540.6

Conserved Domains (5) summary

smart00082
Location:300 → 347

LRRCT; Leucine rich repeat C-terminal domain

COG4886
Location:106 → 301

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:53 → 76

LRR_RI; leucine-rich repeat [structural motif]

pfam01462
Location:23 → 49

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:75 → 135

LRR_8; Leucine rich repeat