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    IPO13 importin 13 [ Homo sapiens (human) ]

    Gene ID: 9670, updated on 9-Dec-2024

    Summary

    Official Symbol
    IPO13provided by HGNC
    Official Full Name
    importin 13provided by HGNC
    Primary source
    HGNC:HGNC:16853
    See related
    Ensembl:ENSG00000117408 MIM:610411; AllianceGenome:HGNC:16853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LGL2; IMP13; KAP13; RANBP13
    Summary
    This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]
    Expression
    Broad expression in testis (RPKM 29.4), brain (RPKM 19.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IPO13 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43946950..43968022)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43818031..43839101)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44412622..44433694)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2918 Neighboring gene uncharacterized LOC101929609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 796 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:44426574-44427773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44436478-44437024 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:44437355-44438554 Neighboring gene uncharacterized LOC124904167 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:44439785-44440618 Neighboring gene diphthamide biosynthesis 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:44440619-44441451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44443584-44444175 Neighboring gene ATPase H+ transporting V0 subunit b

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0724

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    importin-13
    Names
    Ran binding protein 13
    karyopherin 13
    late gestation lung 2
    ran-binding protein 13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014652.4NP_055467.3  importin-13

      See identical proteins and their annotated locations for NP_055467.3

      Status: REVIEWED

      Source sequence(s)
      AB018267, AL357079, BX116797
      Consensus CDS
      CCDS503.1
      UniProtKB/Swiss-Prot
      D3DPY4, O94829, Q5T4X3, Q7LC04, Q96HS3, Q9H8N3, Q9UFR1
      UniProtKB/TrEMBL
      A8K2A8
      Related
      ENSP00000361418.3, ENST00000372343.8
      Conserved Domains (5) summary
      smart00913
      Location:45109
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:117263
      Xpo1; Exportin 1-like protein
      pfam18773
      Location:402441
      Importin_rep; Importin 13 repeat
      pfam18786
      Location:584627
      Importin_rep_2; Importin 13 repeat
      pfam18806
      Location:826900
      Importin_rep_3; Importin 13 repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      43946950..43968022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451069.2XP_024306837.1  importin-13 isoform X1

    2. XM_024451070.2XP_024306838.1  importin-13 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      43818031..43839101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339738.1XP_054195713.1  importin-13 isoform X1

    2. XM_054339739.1XP_054195714.1  importin-13 isoform X1