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    IGSF21 immunoglobin superfamily member 21 [ Homo sapiens (human) ]

    Gene ID: 84966, updated on 27-Nov-2024

    Summary

    Official Symbol
    IGSF21provided by HGNC
    Official Full Name
    immunoglobin superfamily member 21provided by HGNC
    Primary source
    HGNC:HGNC:28246
    See related
    Ensembl:ENSG00000117154 AllianceGenome:HGNC:28246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]
    Expression
    Biased expression in brain (RPKM 11.7), spleen (RPKM 6.4) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IGSF21 in Genome Data Viewer
    Location:
    1p36.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (18107798..18378483)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (17927918..18198544)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (18434292..18704977)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376812 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:18404738-18404927 Neighboring gene long intergenic non-protein coding RNA 1654 Neighboring gene Sharpr-MPRA regulatory region 487 Neighboring gene NANOG hESC enhancer GRCh37_chr1:18425418-18425940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18468715-18469332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18469333-18469948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18473111-18473612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18473613-18474112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18482493-18483371 Neighboring gene IGSF21 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:18501697-18502198 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:18502199-18502698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18525748-18526248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18526249-18526749 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:18527418-18527918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18538061-18538884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18557491-18558139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18575476-18575976 Neighboring gene uncharacterized LOC124903864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18606867-18607381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18607382-18607895 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:18609585-18610784 Neighboring gene uncharacterized LOC124903863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18620236-18621123 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:18622899-18623785 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18624079-18624604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18626609-18627236 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:18633258-18633415 Neighboring gene Sharpr-MPRA regulatory region 11488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18672835-18673336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18673337-18673836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18709612-18710411 Neighboring gene uncharacterized LOC124903865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18733166-18733860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18733861-18734554 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:18794765-18794938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18806502-18807374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18807375-18808246 Neighboring gene kelch domain containing 7A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
    EBI GWAS Catalog
    Genome-wide meta-analysis for severe diabetic retinopathy.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ41177, MGC15730

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synapse maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in trans-synaptic signaling, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in inhibitory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    immunoglobulin superfamily member 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027535.2 RefSeqGene

      Range
      5053..275738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032880.5NP_116269.3  immunoglobulin superfamily member 21 precursor

      See identical proteins and their annotated locations for NP_116269.3

      Status: REVIEWED

      Source sequence(s)
      AK075316, AL356101, BC007618
      Consensus CDS
      CCDS184.1
      UniProtKB/Swiss-Prot
      Q8NBR8, Q96ID5
      Related
      ENSP00000251296.1, ENST00000251296.4
      Conserved Domains (2) summary
      smart00410
      Location:353430
      IG_like; Immunoglobulin like
      cl11960
      Location:369432
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      18107798..18378483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542319.4XP_011540621.1  immunoglobulin superfamily member 21 isoform X3

      Conserved Domains (2) summary
      smart00410
      Location:156233
      IG_like; Immunoglobulin like
      cl11960
      Location:172235
      Ig; Immunoglobulin domain
    2. XM_017002604.3XP_016858093.1  immunoglobulin superfamily member 21 isoform X1

      Conserved Domains (2) summary
      smart00410
      Location:347424
      IG_like; Immunoglobulin like
      cl11960
      Location:363426
      Ig; Immunoglobulin domain
    3. XM_017002605.1XP_016858094.1  immunoglobulin superfamily member 21 isoform X2

      Conserved Domains (2) summary
      smart00410
      Location:276353
      IG_like; Immunoglobulin like
      cl11960
      Location:292355
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      17927918..18198544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339280.1XP_054195255.1  immunoglobulin superfamily member 21 isoform X3

    2. XM_054339278.1XP_054195253.1  immunoglobulin superfamily member 21 isoform X1

    3. XM_054339279.1XP_054195254.1  immunoglobulin superfamily member 21 isoform X2