U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nkx1.2la NK1 transcription factor related 2-like,a [ Danio rerio (zebrafish) ]

    Gene ID: 405755, updated on 9-Dec-2024

    Summary

    Official Symbol
    nkx1.2laprovided by ZNC
    Official Full Name
    NK1 transcription factor related 2-like,aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040615-1
    See related
    Ensembl:ENSDARG00000006350 AllianceGenome:ZFIN:ZDB-GENE-040615-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sax1; zsax1; zgc:101023
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including axis; nervous system; neural tube; periderm; and tail bud. Orthologous to human NKX1-2 (NK1 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See nkx1.2la in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (40754587..40773595)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (40644738..40647705)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 2 (stretch responsive muscle) Neighboring gene MORN repeat containing 4 Neighboring gene protein kinase cGMP-dependent 1a Neighboring gene dickkopf WNT signaling pathway inhibitor 1a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NK1 transcription factor related 2-like,a
    Names
    homeobox protein Sax1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212830.2NP_997995.2  NK1 transcription factor related 2-like,a

      Status: VALIDATED

      Source sequence(s)
      BX294129, CT721252
      UniProtKB/TrEMBL
      A0A8N7V0C0, B8A4P8
      Related
      ENSDARP00000080281.5, ENSDART00000085846.6
      Conserved Domains (1) summary
      pfam00046
      Location:145197
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      40754587..40773595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212825.1XP_068068926.1  NK1 transcription factor related 2-like,a isoform X1

      UniProtKB/TrEMBL
      A0A8N7V0C0, B8A4P8
    2. XM_068212824.1XP_068068925.1  NK1 transcription factor related 2-like,a isoform X1

      UniProtKB/TrEMBL
      A0A8N7V0C0, B8A4P8