spag1a sperm associated antigen 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spag1aprovided by ZNC
Official Full Name: sperm associated antigen 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9443
See related: Ensembl:ENSDARG00000004017 AllianceGenome:ZFIN:ZDB-GENE-030131-9443
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: spag1; cb1089; wu:fj78g10
Summary: Involved in axonemal dynein complex assembly. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including EVL; nervous system; pectoral fin musculature; periderm; and ventral mesenchyme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 28. Orthologous to human SPAG1 (sperm associated antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (11985572..12018446)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (12066044..12098918)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dynein axonemal particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sperm-associated antigen 1A

Names: sperm associated antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089406.2 → NP_001082875.2 sperm-associated antigen 1A

Status: VALIDATED

Source sequence(s)

EH503424, FP236813

UniProtKB/Swiss-Prot

A4QNV4, F1RBN2

UniProtKB/TrEMBL

A0A0H2UKG1, A0A8M1ND21

Related

ENSDARP00000104892.3, ENSDART00000130537.3

Conserved Domains (3) summary

sd00006
Location:263 → 289

TPR; TPR repeat [structural motif]

pfam00515
Location:297 → 328

TPR_1; Tetratricopeptide repeat

pfam13414
Location:263 → 326

TPR_11; TPR repeat