gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnat2provided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-011128-10
See related: Ensembl:ENSDARG00000042529 AllianceGenome:ZFIN:ZDB-GENE-011128-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within detection of light stimulus involved in visual perception. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in head; pineal complex; and visual system. Used to study achromatopsia and cone-rod dystrophy. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to human GNAT2 (G protein subunit alpha transducin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (25225590..25235603, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (25206451..25216464, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study describes several functional differences between transducin gene duplicates resulting from the teleost-specific tetraploidisation.
Title: Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation.
identifed cis-regulatory elements in upstream promoter region of the TalphaC gene; found PRE-1 is a novel cis-regulatory module that is sufficient to enhance initiation of photoreceptor-specific gene expression in differentiating rod and cone photoreceptors
Title: PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors.
analysis of an evolutionarily conserved enhancer of cone photoreceptor-specific expression
Title: A novel, evolutionarily conserved enhancer of cone photoreceptor-specific expression.
Ca2+ also regulates the extent of phosphorylation of unbleached cone pigments. Immunocytochemical analyses revealed that neither light nor cytoplasmic Ca2+ influences the localization of transducin in zebrafish cones.
Title: Visual pigment phosphorylation but not transducin translocation can contribute to light adaptation in zebrafish cones.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of light stimulus involved in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in photoreceptor inner segment	IBA Inferred from Biological aspect of Ancestor more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(t) subunit alpha-2

Names: GNAT3; Galpha t2; T alpha C; Tc alpha; cone transducin alpha subunit; no optokinetic response f; nof; transducin alpha (cone)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131869.2 → NP_571944.1 guanine nucleotide-binding protein G(t) subunit alpha-2

See identical proteins and their annotated locations for NP_571944.1

Status: PROVISIONAL

Source sequence(s)

BC059498

UniProtKB/TrEMBL

F6NNY3, Q6PC25, Q90WX5

Related

ENSDARP00000062362.4, ENSDART00000062363.6

Conserved Domains (2) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:13 → 352

G_alpha; G protein alpha subunit