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    dync1i2b dynein, cytoplasmic 1, intermediate chain 2b [ Danio rerio (zebrafish) ]

    Gene ID: 561612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dync1i2bprovided by ZNC
    Official Full Name
    dynein, cytoplasmic 1, intermediate chain 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090121-1
    See related
    Ensembl:ENSDARG00000103195 AllianceGenome:ZFIN:ZDB-GENE-090121-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk28d02; wu:fk28d02
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in transport along microtubule. Predicted to act upstream of or within microtubule-based movement. Predicted to be part of cytoplasmic dynein complex. Is expressed in female organism. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dync1i2b in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (3932422..3957469)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (3771588..3796661)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene golgi reassembly stacking protein 2 Neighboring gene tousled-like kinase 1b Neighboring gene solute carrier family 25 member 12 Neighboring gene unc-50 homolog (C. elegans)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic Variants in DYNC1I2 Cause Syndromic Microcephaly with Intellectual Disability, Cerebral Malformations, and Dysmorphic Facial Features. Ansar M, et al. Am J Hum Genet, 2019 Jun 6. PMID 31079899, Free PMC Article
    2. SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. See K, et al. Hum Mol Genet, 2014 Apr 1. PMID 24218366
    3. Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Gebauer JM, et al. Matrix Biol, 2016 Jan. PMID 26235539
    4. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein 1 intermediate chain 2; dynein, cytoplasmic 1, intermediate chain 2a-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      3932422..3957469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009302110.4 → XP_009300385.1  dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1

      UniProtKB/TrEMBL
      A0A8M3B334
      Conserved Domains (5) summary
      COG2319
      Location:362 → 606
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:145 → 173
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      pfam14153
      Location:153 → 256
      Spore_coat_CotO; Spore coat protein CotO
      sd00039
      Location:289 → 338
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:283 → 605
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_009302112.4 → XP_009300387.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AT17
      Conserved Domains (5) summary
      COG2319
      Location:316 → 586
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:125 → 153
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      pfam14153
      Location:133 → 236
      Spore_coat_CotO; Spore coat protein CotO
      sd00039
      Location:269 → 318
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:263 → 585
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_009302111.4 → XP_009300386.1  dynein, cytoplasmic 1, intermediate chain 2a-like isoform X2

      UniProtKB/TrEMBL
      A0A0R4IXD8, A0A8M3B058
      Related
      ENSDARP00000141192.1, ENSDART00000159673.3
      Conserved Domains (5) summary
      COG2319
      Location:345 → 589
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:128 → 156
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      pfam14153
      Location:136 → 239
      Spore_coat_CotO; Spore coat protein CotO
      sd00039
      Location:272 → 321
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:266 → 588
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_009302113.4 → XP_009300388.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M3BA49
      Conserved Domains (5) summary
      COG2319
      Location:325 → 569
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:108 → 136
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      pfam14153
      Location:116 → 219
      Spore_coat_CotO; Spore coat protein CotO
      sd00039
      Location:252 → 301
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:246 → 568
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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