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    nrd1a nardilysin a (N-arginine dibasic convertase) [ Danio rerio (zebrafish) ]

    Gene ID: 565850, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nrd1aprovided by ZNC
    Official Full Name
    nardilysin a (N-arginine dibasic convertase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-417
    See related
    Ensembl:ENSDARG00000019596 AllianceGenome:ZFIN:ZDB-GENE-070912-417
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk24c07; wu:fk24c07; si:dkey-193b15.9
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See nrd1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (36828230..36854298)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (36845769..36872043)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103910071 Neighboring gene microRNA mir-2198 Neighboring gene uncharacterized LOC137488017 Neighboring gene SLIT and NTRK-like family, member 3b Neighboring gene family with sequence similarity 163 member Aa Neighboring gene RAB GTPase activating protein 1-like 2 Neighboring gene interferon induced protein 44c1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nardilysin
    XP_005171383.1
    XP_694205.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      36828230..36854298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689113.8 → XP_694205.1  nardilysin

      See identical proteins and their annotated locations for XP_694205.1

      UniProtKB/TrEMBL
      A0A8M2BIM0, B0S6B9
      Conserved Domains (4) summary
      COG1025
      Location:47 → 1029
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:142 → 272
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:298 → 483
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:488 → 769
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    2. XM_005171326.5 → XP_005171383.1  nardilysin

      See identical proteins and their annotated locations for XP_005171383.1

      UniProtKB/TrEMBL
      A0A8M2BIM0, B0S6B9
      Related
      ENSDARP00000117031.1, ENSDART00000135754.2
      Conserved Domains (4) summary
      COG1025
      Location:47 → 1029
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:142 → 272
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:298 → 483
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:488 → 769
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    Nucleotide Protein Strain
    Heading Accession and Version

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