pxna paxillin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pxnaprovided by ZNC
Official Full Name: paxillin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040105-1
See related: Ensembl:ENSDARG00000088590 AllianceGenome:ZFIN:ZDB-GENE-040105-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pxn; wu:fw71f12
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within regulation of protein localization; skeletal muscle tissue development; and somite development. Predicted to be located in cell cortex and cytoskeleton. Is expressed in several structures, including Kupffer's vesicle; eye; myotome; notochord posterior region; and somite. Orthologous to human PXN (paxillin). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (6672870..6718122)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (6110303..6155417)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

paxillin may function in adhesion during the morphogenesis of the early zebrafish embryo
Title: Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myotome development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: paxillin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201588.2 → NP_963882.1 paxillin a

See identical proteins and their annotated locations for NP_963882.1

Status: VALIDATED

Source sequence(s)

AY515510, BQ618129, EB976413

UniProtKB/TrEMBL

Q6R3L1

Related

ENSDARP00000104565.2, ENSDART00000126598.3

Conserved Domains (5) summary

cd09407
Location:359 → 410

LIM2_Paxillin; The second LIM domain of paxillin

cd09409
Location:418 → 470

LIM3_Paxillin; The third LIM domain of paxillin

cd09411
Location:477 → 528

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:300 → 352

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 229

Paxillin; Paxillin family