igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf2bp1provided by ZNC
Official Full Name: insulin-like growth factor 2 mRNA binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-060929-1258
See related: Ensembl:ENSDARG00000061478 AllianceGenome:ZFIN:ZDB-GENE-060929-1258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IMP1; CRDBP; fb96d05; wu:fb18f03; wu:fb96d05; wu:fi72a06; zgc:152963
Summary: Predicted to enable N6-methyladenosine-containing RNA reader activity and mRNA 3'-UTR binding activity. Acts upstream of or within neural retina development and regulation of hepatocyte proliferation. Predicted to be located in P-body and cytoplasmic stress granule. Predicted to be part of CRD-mediated mRNA stability complex. Predicted to be active in cytosol and nucleus. Is expressed in brain; digestive system; and head. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (23518136..23575115, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (23393795..23444567, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
Title: A Mettl16/m(6)A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.
igf2bp1 is a critical factor to regulate hepatic outgrowth via cell proliferation during early liver development in zebrafish.
Title: Igf2bp1 is required for hepatic outgrowth during early liver development in zebrafish.
required during retinal ganglion cell axon outgrowth in vivo
Title: The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo.
Two KH domains of CRD-BP are required for efficient binding to oncogenic mRNAs and for granule formation in zebrafish embryos.
Title: Molecular insights into the coding region determinant-binding protein-RNA interaction through site-directed mutagenesis in the heterogeneous nuclear ribonucleoprotein-K-homology domains.

Submit: New GeneRIF Correction

General gene information

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Markers

fb18f03.x1 (e-PCR)
- UniSTS:203013

fi72a06.x1 (e-PCR)
- UniSTS:197910

fc41e07.x1 (e-PCR)
- UniSTS:188145

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in CRD-mediated mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CRD-mediated mRNA stability complex	ISS Inferred from Sequence or Structural Similarity more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 1

Names: IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; VICKZ family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076559.2 → NP_001070027.2 insulin-like growth factor 2 mRNA-binding protein 1

Status: VALIDATED

Source sequence(s)

BX682553, BX682558

UniProtKB/Swiss-Prot

Q08CK7

UniProtKB/TrEMBL

A0A0B4J1A6, A0A8M1NAV6

Related

ENSDARP00000082159.4, ENSDART00000087726.7

Conserved Domains (5) summary

smart00322
Location:489 → 559

KH; K homology RNA-binding domain

COG0724
Location:2 → 87

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00105
Location:201 → 264

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12625
Location:1 → 77

RRM1_IGF2BP1; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

cd12628
Location:81 → 156

RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)