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    mfsd12a major facilitator superfamily domain containing 12a [ Danio rerio (zebrafish) ]

    Gene ID: 561964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mfsd12aprovided by ZNC
    Official Full Name
    major facilitator superfamily domain containing 12aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4642
    See related
    Ensembl:ENSDARG00000061908 AllianceGenome:ZFIN:ZDB-GENE-030131-4642
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wz7872; fd45a11; wu:fd45a11; zgc:158256; si:dkey-218h11.4
    Summary
    Predicted to enable cysteine transmembrane transporter activity. Acts upstream of or within pigment accumulation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human MFSD12 (major facilitator superfamily domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mfsd12a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (23081227..23099644)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (23425385..23443993)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene MAPK interacting serine/threonine kinase 2a Neighboring gene casein kinase 1, gamma 2a Neighboring gene NACHT domain containing pseudogene Neighboring gene uncharacterized LOC103910044 Neighboring gene paired related homeobox 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Loci associated with skin pigmentation identified in African populations. Crawford NG, et al. Science, 2017 Nov 17. PMID 29025994, Free PMC Article
    2. A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Iovine MK, et al. Genomics, 2002 Jun. PMID 12036288
    3. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158256

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within pigment accumulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pigment metabolic process involved in pigmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of melanin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 12a
    Names
    mfsd12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044972.1 → NP_001038437.1  major facilitator superfamily domain-containing protein 12a

      Status: PROVISIONAL

      Source sequence(s)
      BX548024
      UniProtKB/TrEMBL
      A0A8M1N9N8, Q1LWK8
      Related
      ENSDARP00000083300.4, ENSDART00000088867.5
      Conserved Domains (2) summary
      pfam07690
      Location:18 → 411
      MFS_1; Major Facilitator Superfamily
      cl21472
      Location:8 → 386
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      23081227..23099644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171209.5 → XP_005171266.1  major facilitator superfamily domain-containing protein 12a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIL3, F1R9L4
      Related
      ENSDARP00000090476.2, ENSDART00000099702.4
      Conserved Domains (2) summary
      pfam07690
      Location:18 → 411
      MFS_1; Major Facilitator Superfamily
      cl21472
      Location:8 → 386
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein Strain
    Heading Accession and Version

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