igf2a insulin-like growth factor 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igf2aprovided by ZNC
Official Full Name: insulin-like growth factor 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991111-3
See related: Ensembl:ENSDARG00000018643 AllianceGenome:ZFIN:ZDB-GENE-991111-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: igf2; igf2b; IGF-II; zgc:91781; wu:fc26e03
Summary: Enables insulin-like growth factor receptor binding activity. Acts upstream of or within notochord development; somitogenesis; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; digestive system; female organism; musculature system; and notochord. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (48870500..48876480)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (48597724..48603704)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ith respect to the different IGFs produced locally, a decrease in igf1a expression and a significant increase in both igf2a and igf2b expression was observed, suggesting that igf1a is not directly involved in fin regeneration. Overall, the results revealed that excess GH enhances fin regeneration in zebrafish through igf2a and igf2b expression, acting indirectly on this major physiological process.
Title: GH indirectly enhances the regeneration of transgenic zebrafish fins through IGF2a and IGF2b.
Igf2 regulates early neural and cardiovascular development in zebrafish embryos.
Title: Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos.
zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.
Title: Targeted gene knockdown in zebrafish reveals distinct intraembryonic functions for insulin-like growth factor II signaling.
The IGF2 expression has also been reported at earlier stages in fish.
Title: Insulin-like growth factor signaling in fish.

Submit: New GeneRIF Correction

General gene information

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Markers

ha2747 (e-PCR)
- UniSTS:515592

igf2 (e-PCR), detects polymorphism
- UniSTS:205594

fc26e03.x1 (e-PCR)
- UniSTS:187867

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of activated T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2a

Names: etID31232.25; insulin-like growth factor 2; insulin-like growth factor 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131433.1 → NP_571508.1 insulin-like growth factor 2a precursor

See identical proteins and their annotated locations for NP_571508.1

Status: PROVISIONAL

Source sequence(s)

AF194333

UniProtKB/TrEMBL

Q9PUD0

Related

ENSDARP00000016954.4, ENSDART00000009642.7

Conserved Domains (2) summary

cd04368
Location:40 → 104

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

pfam08365
Location:129 → 184

IGF2_C; Insulin-like growth factor II E-peptide