prox1a prospero homeobox 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prox1aprovided by ZNC
Official Full Name: prospero homeobox 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-397
See related: Ensembl:ENSDARG00000055158 AllianceGenome:ZFIN:ZDB-GENE-980526-397
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prox1; zgc:111888
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including forebrain neuron development; lymphangiogenesis; and neuromast development. Located in nucleus. Is expressed in several structures, including digestive system; mesoderm; nervous system; pleuroperitoneal region; and trunk vasculature. Orthologous to human PROX1 (prospero homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (32819283..32866570, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (32866772..32914311, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds.
Title: Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds.
Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish.
Title: Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish.
Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina.
Title: Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina.
Overall, the data show that HHEX controls blood vessel and lymphatic vessel formation by regulating the VEGFC/FLT4/PROX1 signaling axis.
Title: HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
using a transgenic reporter line, we show that prox1a is initially expressed in different endothelial compartments, becoming restricted to lymphatic endothelial cells only at later stages
Title: Divergence of zebrafish and mouse lymphatic cell fate specification pathways.
Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.
Title: The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line.
Our findings indicate that prox1 activity is crucial for the proper development of the otp1-positive hypothalamic neuronal precursors to their terminal CA phenotype
Title: Crucial role of zebrafish prox1 in hypothalamic catecholaminergic neurons development.
Prox1 functions as a tissue-specific coregulator of Ff1b
Title: Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within forebrain neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuromast deposition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromast hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prospero homeobox protein 1a

Names: prospero-related homeobox gene 1; prospero-related homeobox gene 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131405.2 → NP_571480.2 prospero homeobox protein 1a

See identical proteins and their annotated locations for NP_571480.2

Status: PROVISIONAL

Source sequence(s)

AY032595

UniProtKB/TrEMBL

Q90ZL7

Related

ENSDARP00000134086.2, ENSDART00000167292.2

Conserved Domains (1) summary

pfam05044
Location:581 → 732

HPD; Homeo-prospero domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

32819283..32866570 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068214325.1 → XP_068070426.1 prospero homeobox protein 1a isoform X1
XM_068214326.1 → XP_068070427.1 prospero homeobox protein 1a isoform X2

UniProtKB/TrEMBL

A0A0R4IFI2, A0A8M2B5N8, F1QAE1
XM_068214323.1 → XP_068070424.1 prospero homeobox protein 1a isoform X1
XM_068214324.1 → XP_068070425.1 prospero homeobox protein 1a isoform X1