U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sema4e semaphorin 4e [ Danio rerio (zebrafish) ]

    Gene ID: 796377, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sema4eprovided by ZNC
    Official Full Name
    semaphorin 4eprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990715-7
    See related
    Ensembl:ENSDARG00000052997 AllianceGenome:ZFIN:ZDB-GENE-990715-7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sema7; semaZ7
    Summary
    Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Predicted to be involved in several processes, including axon guidance; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; pectoral fin bud; and pharyngeal arch. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sema4e in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (49568980..49603673)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (49834750..49869739)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like 1a Neighboring gene signal transducing adaptor family member 2a Neighboring gene si:ch211-209f23.3 Neighboring gene si:ch211-209f23.6 Neighboring gene cactin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular cloning and expression of two novel zebrafish semaphorins. Halloran MC, et al. Mech Dev, 1998 Aug. PMID 9867349
    2. Cellular and molecular bases of axonal pathfinding during embryogenesis of the fish central nervous system. Bernhardt RR. J Neurobiol, 1999 Jan. PMID 10027569
    3. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
    4. Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Jiang L, et al. Proc Natl Acad Sci U S A, 2014 Apr 8. PMID 24706903, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC100758

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    semaphorin-4E
    Names
    sema Z7
    semaphorin-7
    semaphorin-Z7

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083865.1 → NP_001077334.1  semaphorin-4E isoform 2 precursor

      See identical proteins and their annotated locations for NP_001077334.1

      Status: PROVISIONAL

      Source sequence(s)
      CU458994
      UniProtKB/TrEMBL
      A4JYS3
      Related
      ENSDARP00000056251.5, ENSDART00000056252.7
      Conserved Domains (3) summary
      cd11260
      Location:45 → 500
      Sema_4E; The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E)
      smart00423
      Location:501 → 555
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl11960
      Location:567 → 640
      Ig; Immunoglobulin domain

    2. NM_131049.1 → NP_571124.1  semaphorin-4E isoform 1 precursor

      See identical proteins and their annotated locations for NP_571124.1

      Status: PROVISIONAL

      Source sequence(s)
      AF073289
      UniProtKB/Swiss-Prot
      Q9YHX4
      UniProtKB/TrEMBL
      Q1MT68
      Conserved Domains (3) summary
      cd11260
      Location:45 → 500
      Sema_4E; The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E)
      smart00423
      Location:501 → 555
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl11960
      Location:567 → 640
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      49568980..49603673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481386.2 → XP_021337061.1  semaphorin-4E isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLC9, F1QNC4
      Related
      ENSDARP00000101012.3, ENSDART00000109471.5
      Conserved Domains (3) summary
      cd11260
      Location:45 → 500
      Sema_4E; The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E)
      smart00423
      Location:501 → 555
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl11960
      Location:567 → 640
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9YHX4.1 GenPept UniProtKB/Swiss-Prot:Q9YHX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools