farsa phenylalanyl-tRNA synthetase subunit alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: farsaprovided by ZNC
Official Full Name: phenylalanyl-tRNA synthetase subunit alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050512-2
See related: Ensembl:ENSDARG00000098825 AllianceGenome:ZFIN:ZDB-GENE-050512-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: farsla; wu:fj21a11; zgc:136506; zgc:158185
Summary: Predicted to enable magnesium ion binding activity and phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to act upstream of or within tRNA aminoacylation and translation. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; digestive system; optic cup; pectoral fin bud; and swim bladder. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (13879447..13901074)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (13729601..13751228)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phenylalanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylalanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables phenylalanine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phenylalanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in phenylalanyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phenylalanine-tRNA ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phenylalanine--tRNA ligase alpha subunit

Names: pheRS; phenylalanine--tRNA ligase alpha chain; phenylalanyl-tRNA synthetase alpha chain; phenylalanyl-tRNA synthetase, alpha subunit

NP_001038760.2

EC 6.1.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045295.2 → NP_001038760.2 phenylalanine--tRNA ligase alpha subunit

See identical proteins and their annotated locations for NP_001038760.2

Status: VALIDATED

Source sequence(s)

BC116564, CK028671

UniProtKB/Swiss-Prot

Q1JPX3, Q6NYF9

Related

ENSDARP00000132548.1, ENSDART00000164767.2

Conserved Domains (2) summary

PLN02853
Location:3 → 496

PLN02853; Probable phenylalanyl-tRNA synthetase alpha chain

cd00496
Location:225 → 483

PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...