mapk14a mitogen-activated protein kinase 14a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mapk14aprovided by ZNC
Official Full Name: mitogen-activated protein kinase 14aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010202-2
See related: Ensembl:ENSDARG00000000857 AllianceGenome:ZFIN:ZDB-GENE-010202-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p38; p38a; zp38a; MAPK14; fk28c03; zeh1243; hm:zeh1243; wu:fk28c03
Summary: Enables MAP kinase activity. Involved in cellular response to UV; embryonic cleavage; and p38MAPK cascade. Acts upstream of or within regulation of collateral sprouting in absence of injury; regulation of protein stability; and somitogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; otic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (23827541..23860719)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (23806189..23839480)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Title: P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Adult zebrafish cardiomyocytes express active p38alpha MAPK, which is switched off upon entry into mitosis.
Title: p38α MAPK regulates myocardial regeneration in zebrafish.
Dkk3r regulates p38a phosphorylation to maintain Smad4 stability, in turn enabling the Smad2.Smad3a.Smad4 complex to form and activate the myf5 promoter.
Title: dickkopf-3-related gene regulates the expression of zebrafish myf5 gene through phosphorylated p38a-dependent Smad4 activity.

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General gene information

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Markers

fk28c03.y1 (e-PCR)
- UniSTS:200746

fd03e12.y1 (e-PCR)
- UniSTS:194881

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to UV	IDA Inferred from Direct Assay more info
involved_in embryonic cleavage	IDA Inferred from Direct Assay more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitogen-activated protein kinase 14A

Names: MAP kinase 14A; MAP kinase p38a; MAPK 14A; etID18993.8; mitogen-activated protein kinase p38a

NP_571797.1

EC 2.7.11.24

XP_005167118.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131722.1 → NP_571797.1 mitogen-activated protein kinase 14A

See identical proteins and their annotated locations for NP_571797.1

Status: PROVISIONAL

Source sequence(s)

AB030897

UniProtKB/Swiss-Prot

Q9DGE1, Q9DGE2

UniProtKB/TrEMBL

B2GPM7

Related

ENSDARP00000040361.4, ENSDART00000040362.5

Conserved Domains (2) summary

cd07877
Location:7 → 351

STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

smart00220
Location:25 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

23827541..23860719

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167061.5 → XP_005167118.1 mitogen-activated protein kinase 14A isoform X1

UniProtKB/TrEMBL

A0A2R8QE41, A0A8M2BEF0

Related

ENSDARP00000147688.1, ENSDART00000187430.1

Conserved Domains (2) summary

cd07877
Location:7 → 351

STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

smart00220
Location:25 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain