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    cax1 cation/H+ exchanger protein 1 [ Danio rerio (zebrafish) ]

    Gene ID: 560283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cax1provided by ZNC
    Official Full Name
    cation/H+ exchanger protein 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3044
    See related
    Ensembl:ENSDARG00000045601 AllianceGenome:ZFIN:ZDB-GENE-030131-3044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc25f10; zgc:136271; si:dkey-180p18.2
    Summary
    Predicted to enable calcium:proton antiporter activity. Acts upstream of or within calcium ion transport and neural crest cell development. Located in endomembrane system. Is expressed in neural crest cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cax1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (14981846..14990888)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (14983091..14992133)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 33a Neighboring gene smoothened, frizzled class receptor Neighboring gene kelch domain containing 10 Neighboring gene zinc finger, C3HC-type containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development. Manohar M, et al. Biochemistry, 2010 Aug 10. PMID 20578725
    2. Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis. Sedykh I, et al. Dev Biol, 2017 Sep 1. PMID 28689736, Free PMC Article
    3. The gene regulatory basis of genetic compensation during neural crest induction. Dooley CM, et al. PLoS Genet, 2019 Jun. PMID 31199790, Free PMC Article
    4. A single-cell transcriptome atlas for zebrafish development. Farnsworth DR, et al. Dev Biol, 2020 Mar 15. PMID 31782996, Free PMC Article
    5. Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Pohl J, et al. Chemosphere, 2021 Aug. PMID 34088109

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. initiate characterization of a zebrafish CAX (Cax1); In zebrafish embryos, cax1 was specifically expressed in neural crest cells and was required for animal growth and development.
      Title: Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136271

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neural crest cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cation/H+ exchanger protein 1
    Names
    type II CAX cation/proton exchanger

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025507.3 → NP_001020678.2  cation/H+ exchanger protein 1

      See identical proteins and their annotated locations for NP_001020678.2

      Status: PROVISIONAL

      Source sequence(s)
      BC133106
      UniProtKB/TrEMBL
      A3KMS2, Q156I9, Q5RH62
      Related
      ENSDARP00000067045.4, ENSDART00000067046.5
      Conserved Domains (3) summary
      COG0387
      Location:354 → 759
      ChaA; Ca2+/H+ antiporter [Inorganic ion transport and metabolism]
      pfam01699
      Location:613 → 757
      Na_Ca_ex; Sodium/calcium exchanger protein
      pfam03733
      Location:156 → 205
      YccF; Inner membrane component domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      14981846..14990888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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