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    pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [ Danio rerio (zebrafish) ]

    Gene ID: 554477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pfkfb3provided by ZNC
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2724
    See related
    Ensembl:ENSDARG00000001953 AllianceGenome:ZFIN:ZDB-GENE-040426-2724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73257; wu:fc31e01
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to act upstream of or within fructose metabolic process and phosphorylation. Predicted to be active in cytosol. Is expressed in Purkinje cell. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pfkfb3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25473022..25485419, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25483824..25496252, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene Scm like with four mbt domains 2 Neighboring gene protein kinase C, theta Neighboring gene RNA binding motif protein 17 Neighboring gene interleukin 15 receptor subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization. Ratnayake R, et al. Chembiochem, 2020 Aug 17. PMID 32237262, Free PMC Article
    2. Role of PFKFB3-driven glycolysis in vessel sprouting. De Bock K, et al. Cell, 2013 Aug 1. PMID 23911327
    3. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Facchinello N, et al. Cell Death Dis, 2021 Jan 19. PMID 33469036, Free PMC Article
    4. Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state. Helker CS, et al. Elife, 2020 Sep 21. PMID 32955436, Free PMC Article
    5. Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation. Mehjabin R, et al. Fish Shellfish Immunol, 2019 Apr. PMID 30716520

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
    Names
    6-phosphofructo-2-kinase
    fructose-2,6-biphosphatase 3
    NP_998562.1
    XP_005164876.1
    XP_005164877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213397.1 → NP_998562.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

      See identical proteins and their annotated locations for NP_998562.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060925
      UniProtKB/TrEMBL
      A0A8M1PF37, Q6P951
      Related
      ENSDARP00000041401.7, ENSDART00000041402.9
      Conserved Domains (2) summary
      pfam00300
      Location:252 → 435
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:31 → 249
      6PF2K; 6-phosphofructo-2-kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      25473022..25485419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164819.5 → XP_005164876.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IBD1, A0A8M2BC17
      Related
      ENSDARP00000130144.1, ENSDART00000159941.2
      Conserved Domains (2) summary
      pfam00300
      Location:252 → 435
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:31 → 249
      6PF2K; 6-phosphofructo-2-kinase

    2. XM_005164820.5 → XP_005164877.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BC55
      Conserved Domains (2) summary
      pfam00300
      Location:252 → 435
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:31 → 249
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein Strain
    Heading Accession and Version

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