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    arfgap2 ADP-ribosylation factor GTPase activating protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 641490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arfgap2provided by ZNC
    Official Full Name
    ADP-ribosylation factor GTPase activating protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051120-177
    See related
    Ensembl:ENSDARG00000067601 AllianceGenome:ZFIN:ZDB-GENE-051120-177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7148924; zgc:123303
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle. Predicted to be located in Golgi membrane. Orthologous to human ARFGAP2 (ADP ribosylation factor GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arfgap2 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44849852..44877073)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44856361..44883619)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 118 member B Neighboring gene SRP receptor subunit alpha Neighboring gene si:ch211-71n6.4 Neighboring gene peroxisomal biogenesis factor 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123303

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037430.1 → NP_001032507.1  ADP-ribosylation factor GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_001032507.1

      Status: PROVISIONAL

      Source sequence(s)
      BC108014
      UniProtKB/TrEMBL
      Q32PR4
      Related
      ENSDARP00000088098.3, ENSDART00000097328.5
      Conserved Domains (3) summary
      PLN03114
      Location:1 → 483
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      pfam01412
      Location:13 → 117
      ArfGap; Putative GTPase activating protein for Arf
      pfam12329
      Location:255 → 316
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      44849852..44877073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159248.4 → XP_005159305.1  ADP-ribosylation factor GTPase-activating protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5S0
      Conserved Domains (3) summary
      PLN03114
      Location:1 → 498
      PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
      pfam01412
      Location:13 → 117
      ArfGap; Putative GTPase activating protein for Arf
      pfam12329
      Location:270 → 331
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    Nucleotide Protein Strain
    Heading Accession and Version

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