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    ccnt2a cyclin T2a [ Danio rerio (zebrafish) ]

    Gene ID: 327568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccnt2aprovided by ZNC
    Official Full Name
    cyclin T2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5779
    See related
    Ensembl:ENSDARG00000036685 AllianceGenome:ZFIN:ZDB-GENE-030131-5779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cycT; ccnt2; zgc:55357; wu:fi17h07
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of DNA-templated transcription, elongation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Orthologous to human CCNT2 (cyclin T2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ccnt2a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (23234233..23242684, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (23423364..23431820, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene LY6/PLAUR domain containing 6B Neighboring gene kinesin family member 5C Neighboring gene uncharacterized LOC110440046 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene transmembrane protein 163a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Xiao B, et al. Zebrafish, 2017 Jun. PMID 28318412
    2. Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. Mirbahai L, et al. BMC Genomics, 2011 Jan 4. PMID 21205313, Free PMC Article
    3. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-T2a
    Names
    cyclin T2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193381.1 → NP_001180310.1  cyclin-T2a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BM776488, BX936418, EB771057
      UniProtKB/TrEMBL
      A0A2R8QAB1, A0A8M1NUM2
      Related
      ENSDARP00000151430.1, ENSDART00000179770.1
      Conserved Domains (1) summary
      pfam00134
      Location:12 → 148
      Cyclin_N; Cyclin, N-terminal domain

    2. NM_199828.2 → NP_956122.1  cyclin-T2a isoform 2

      See identical proteins and their annotated locations for NP_956122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BM776488, BX936418, EB771057, EH432270, EH526493
      UniProtKB/TrEMBL
      A0A8M1PDI5, Q803Q8
      Related
      ENSDARP00000053281.4, ENSDART00000053282.6
      Conserved Domains (1) summary
      pfam00134
      Location:12 → 148
      Cyclin_N; Cyclin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      23234233..23242684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_011016723.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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