nae1 nedd8 activating enzyme E1 subunit 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nae1provided by ZNC
Official Full Name: nedd8 activating enzyme E1 subunit 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1552
See related: Ensembl:ENSDARG00000011301 AllianceGenome:ZFIN:ZDB-GENE-040426-1552
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: appbp1; zgc:66148
Summary: Predicted to enable ubiquitin-like modifier activating enzyme activity. Predicted to contribute to NEDD8 activating enzyme activity. Predicted to be involved in protein neddylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (44773912..44794313, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (44434687..44455088, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NEDD8 activating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein neddylation	IEA Inferred from Electronic Annotation more info
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info
involved_in protein neddylation	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NEDD8-activating enzyme E1 regulatory subunit

Names: APP-BP1; amyloid beta precursor protein binding protein 1; amyloid protein-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200499.1 → NP_956793.1 NEDD8-activating enzyme E1 regulatory subunit

See identical proteins and their annotated locations for NP_956793.1

Status: PROVISIONAL

Source sequence(s)

BC055513

UniProtKB/Swiss-Prot

A7MBR8, Q7SXP2, Q7ZUA4

Related

ENSDARP00000026192.5, ENSDART00000019270.8

Conserved Domains (2) summary

COG0476
Location:6 → 164

ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]

cd01493
Location:10 → 531

APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...