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    suv39h1a SUV39H1 histone lysine methyltransferase a [ Danio rerio (zebrafish) ]

    Gene ID: 445198, updated on 27-Dec-2024

    Summary

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    Official Symbol
    suv39h1aprovided by ZNC
    Official Full Name
    SUV39H1 histone lysine methyltransferase aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-111
    See related
    Ensembl:ENSDARG00000026799 AllianceGenome:ZFIN:ZDB-GENE-040801-111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fe02c04; suv39h1; wu:fe02c04; zgc:101027
    Summary
    Enables histone H3K9 methyltransferase activity. Acts upstream of or within exocrine pancreas development and retina morphogenesis in camera-type eye. Predicted to be located in chromosome, centromeric region. Predicted to be active in nucleus. Is expressed in several structures, including blastomere; digestive system; head; integument; and trunk musculature. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See suv39h1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23395506..23405093)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23374204..23383866)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkey-16n15.3 Neighboring gene si:dkey-16n15.6 Neighboring gene uncharacterized LOC137496345 Neighboring gene G protein-coupled receptor 173 Neighboring gene forkhead box P3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The histone methyltransferase SUV39H1 suppresses embryonal rhabdomyosarcoma formation in zebrafish. Albacker CE, et al. PLoS One, 2013. PMID 23705022, Free PMC Article
    2. Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Rai K, et al. Mol Cell Biol, 2006 Oct. PMID 16980612, Free PMC Article
    3. Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish. Mishima Y, et al. Mol Cell, 2016 Mar 17. PMID 26990990
    4. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
    5. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone H3K9 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K9 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9me2 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SUV39H1-A
    Names
    su(var)3-9 homolog 1-A
    suppressor of variegation 3-9 homolog 1
    suppressor of variegation 3-9 homolog 1-A
    suppressor of variegation 3-9 homolog 1a
    suppressor of variegation 3-9-like 1a
    NP_001003592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003592.1 → NP_001003592.1  histone-lysine N-methyltransferase SUV39H1-A

      See identical proteins and their annotated locations for NP_001003592.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076417
      UniProtKB/Swiss-Prot
      A5XBP4, B0S580, Q6DGD3
      Related
      ENSDARP00000034818.6, ENSDART00000038955.7
      Conserved Domains (3) summary
      smart00317
      Location:242 → 365
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam00385
      Location:44 → 91
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam05033
      Location:139 → 234
      Pre-SET; Pre-SET motif

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23395506..23405093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DGD3.2 GenPept UniProtKB/Swiss-Prot:Q6DGD3

    Gene LinkOut

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