cdh2 cadherin 2, type 1, N-cadherin (neuronal) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cdh2provided by ZNC
Official Full Name: cadherin 2, type 1, N-cadherin (neuronal)provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-171
See related: Ensembl:ENSDARG00000018693 AllianceGenome:ZFIN:ZDB-GENE-990415-171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bib; glo; lyr; pac; ncad; wu:fb47h04
Summary: Predicted to enable beta-catenin binding activity; cadherin binding activity; and calcium ion binding activity. Involved in cell-cell adhesion and neural tube formation. Acts upstream of or within several processes, including axial mesoderm structural organization; embryonic morphogenesis; and nervous system development. Located in cell-cell junction; perinuclear region of cytoplasm; and presynaptic membrane. Part of catenin complex. Is expressed in several structures, including germ ring; immature eye; mesoderm; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (17740104..17819238)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (17840521..17919655)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microtubules and motor proteins support zebrafish neuronal migration by directing cargo.
Title: Microtubules and motor proteins support zebrafish neuronal migration by directing cargo.
Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate.
Title: Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate.
MyoVb is required for cardiomyocyte endosomal recycling and appropriate N-cadherin localization during the onset of chamber ballooning.
Title: Myosin Vb is required for correct trafficking of N-cadherin and cardiac chamber ballooning.
These results also suggest the possibility that E- and N-cadherin have heterophilic interactions during early morphogenesis of the embryo; interactions that might help balance the variety of cell affinities needed during embryonic development.
Title: Probing Cadherin Interactions in Zebrafish with E- and N-Cadherin Missense Mutants.
N-cadherin is involved in neuronal activity-dependent regulation of myelinating capacity of zebrafish individual oligodendrocytes in vivo.
Title: N-Cadherin is Involved in Neuronal Activity-Dependent Regulation of Myelinating Capacity of Zebrafish Individual Oligodendrocytes In Vivo.
N-cadherin-defective endodermal cells resembled ectodermal cells; expression of N-cadherin sufficient to induce internalization of ectodermal cells
Title: Endodermal germ-layer formation through active actin-driven migration triggered by N-cadherin.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin is required for lens fiber growth
Title: Cell division and cadherin-mediated adhesion regulate lens epithelial cell movement in zebrafish.
Newly synthesized N-cadherin molecules move from the lateral to the basal surface of cardiomyocytes during trabeculation. This localization requires Erbb2 signaling.
Title: N-cadherin relocalization during cardiac trabeculation.
Throughout somitogenesis, Cadherin2 promotes extracellular matrix (ECM) assembly along tissue boundaries and inhibits ECM assembly in the tissue mesenchyme.
Title: A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis.
Cdon is required to localize N-cadherin to the cell membrane in migratory neural crest cells for directed migration.
Title: Cdon promotes neural crest migration by regulating N-cadherin localization.

Submit: New GeneRIF Correction See all GeneRIFs (35)

General gene information

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Markers

G47057 (e-PCR)
- UniSTS:107847

fb47h04.x1 (e-PCR)
- UniSTS:190600

ncad (e-PCR)
- UniSTS:204730

G39526 (e-PCR)
- UniSTS:65011

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axial mesoderm structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration in hindbrain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in somitogenic axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell-cell adhesion via plasma-membrane adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal convergence	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal convergence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ectoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigment cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory epithelium regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord patterning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse assembly	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in desmosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info
located_in intercalated disc	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cadherin-2

Names: cadherin 2, neuronal; glass onion; labyrinth; n-cadherin; neural cadherin; parachute

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131081.2 → NP_571156.2 cadherin-2 precursor

See identical proteins and their annotated locations for NP_571156.2

Status: VALIDATED

Source sequence(s)

AF418565, CR759908, CT827862

UniProtKB/Swiss-Prot

Q8UVQ7, Q90275

UniProtKB/TrEMBL

A3KNA3, Q1L8K3

Related

ENSDARP00000003949.9, ENSDART00000024627.11

Conserved Domains (5) summary

cd11304
Location:260 → 365

Cadherin_repeat; Cadherin tandem repeat domain

smart01055
Location:27 → 117

Cadherin_pro; Cadherin prodomain like

pfam00028
Location:595 → 688

Cadherin; Cadherin domain

pfam01049
Location:746 → 889

Cadherin_C; Cadherin cytoplasmic region

cl09101
Location:150 → 250

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus