glra1 glycine receptor, alpha 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glra1provided by ZNC
Official Full Name: glycine receptor, alpha 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-991117-1
See related: Ensembl:ENSDARG00000012019 AllianceGenome:ZFIN:ZDB-GENE-991117-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: [a]Z1
Summary: Enables extracellularly glycine-gated chloride channel activity and glycine binding activity. Acts upstream of or within several processes, including monoatomic ion transport; regulation of neuron differentiation; and response to amino acid. Located in membrane. Is expressed in brain; hindbrain; and spinal cord. Used to study hyperekplexia. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (25816973..25909344)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (25519653..25608776)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish alpha1 and rat alpha1beta recombinant glycine receptors.
Title: Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors.
Mechanism of gating and partial agonist action in the glycine receptor.
Title: Mechanism of gating and partial agonist action in the glycine receptor.
Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.
Title: Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.
cryo-microscopy structures of the zebrafish alpha1 GlyR with strychnine, glycine, or glycine and ivermectin (glycine/ivermectin)
Title: Glycine receptor mechanism elucidated by electron cryo-microscopy.
A new alphaZ1 subunit likely arising from the alphaZ1 gene by an alternative splice process is cloned and characterized; mRNA expression of embryonic and adult alphaZ1 and its spliced product, alphaZ1L, is restricted to the central nervous system.
Title: A novel glycine receptor alpha Z1 subunit variant in the zebrafish brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated chloride channel activity	IDA Inferred from Direct Assay more info
enables extracellularly glycine-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ethanol	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to amino acid	IDA Inferred from Direct Assay more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycine receptor subunit alphaZ1

Names: GlyR [a]Z1; glycine receptor, alphaZ1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131402.1 → NP_571477.1 glycine receptor subunit alphaZ1 precursor

See identical proteins and their annotated locations for NP_571477.1

Status: PROVISIONAL

Source sequence(s)

AJ005812

UniProtKB/Swiss-Prot

O93430

UniProtKB/TrEMBL

B3DHZ5, Q8QG93

Related

ENSDARP00000003268.6, ENSDART00000005499.9

Conserved Domains (1) summary

TIGR00860
Location:7 → 433

LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

25816973..25909344

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480963.2 → XP_021336638.1 glycine receptor subunit alphaZ1 isoform X1

UniProtKB/TrEMBL

A0A8M9QAU4, E9QC31, Q8QG93

Related

ENSDARP00000116295.1, ENSDART00000136733.4

Conserved Domains (1) summary

TIGR00860
Location:7 → 446

LIC; Cation transporter family protein
XM_068213155.1 → XP_068069256.1 glycine receptor subunit alphaZ1 isoform X2

UniProtKB/TrEMBL

Q8QG93