ift80 intraflagellar transport 80 homolog (Chlamydomonas) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ift80provided by ZNC
Official Full Name: intraflagellar transport 80 homolog (Chlamydomonas)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-50
See related: Ensembl:ENSDARG00000038879 AllianceGenome:ZFIN:ZDB-GENE-041212-50
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fj11a06; zgc:101763
Summary: Acts upstream of or within several processes, including cilium assembly; convergent extension; and retina morphogenesis in camera-type eye. Predicted to be located in motile cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. Is expressed in several structures, including eye; notochord; pectoral fin; pectoral fin bud; and pronephric duct. Used to study asphyxiating thoracic dystrophy; asphyxiating thoracic dystrophy 2; and ciliopathy. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Orthologous to human IFT80 (intraflagellar transport 80). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (1494493..1534232, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (1529584..1569333, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intraflagellar transport protein 80 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008625.1 → NP_001008625.1 intraflagellar transport protein 80 homolog

See identical proteins and their annotated locations for NP_001008625.1

Status: PROVISIONAL

Source sequence(s)

BC086735

UniProtKB/TrEMBL

A0A8M2BKN3, Q5PRA9

Related

ENSDARP00000056762.3, ENSDART00000056763.5

Conserved Domains (3) summary

COG2319
Location:12 → 310

WD40; WD40 repeat [General function prediction only]

sd00039
Location:61 → 104

7WD40; WD40 repeat [structural motif]

cl02567
Location:13 → 287

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...