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    bcat1 branched chain amino-acid transaminase 1, cytosolic [ Danio rerio (zebrafish) ]

    Gene ID: 337412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bcat1provided by ZNC
    Official Full Name
    branched chain amino-acid transaminase 1, cytosolicprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9358
    See related
    Ensembl:ENSDARG00000045568 AllianceGenome:ZFIN:ZDB-GENE-030131-9358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj66g02; zgc:73157; wu:fj66g02
    Summary
    Predicted to enable branched-chain-amino-acid transaminase activity. Predicted to be involved in L-leucine biosynthetic process and L-valine biosynthetic process. Predicted to act upstream of or within amino acid biosynthetic process and branched-chain amino acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in central nervous system; liver; muscle; and neural tube. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bcat1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17279966..17297431)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (17290953..17308444)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491539 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene lymphoid-restricted membrane protein Neighboring gene insulin-like growth factor 1 Neighboring gene nucleoporin 37 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial dysfunction, apoptosis and transcriptomic alterations induced by four strobilurins in zebrafish (Danio rerio) early life stages. Jiang J, et al. Environ Pollut, 2019 Oct. PMID 31344535
    2. Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Mansfeld J, et al. Nat Commun, 2015 Dec 1. PMID 26620638, Free PMC Article
    3. Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle. Li Y, et al. PLoS Comput Biol, 2015 Feb. PMID 25714999, Free PMC Article
    4. Peroxisomal proliferator-activated receptor α-b deficiency induces the reprogramming of nutrient metabolism in zebrafish. Li LY, et al. J Physiol, 2020 Oct. PMID 32710562
    5. Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. Nakajima H, et al. PLoS One, 2011. PMID 22046393, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables L-isoleucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-leucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-valine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-valine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branched-chain amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    branched-chain-amino-acid aminotransferase, cytosolic
    Names
    branched chain aminotransferase 1, cytosolic
    NP_956358.1
    XP_005164772.1
    XP_009298529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200064.1 → NP_956358.1  branched-chain-amino-acid aminotransferase, cytosolic

      See identical proteins and their annotated locations for NP_956358.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059513
      UniProtKB/TrEMBL
      Q6PC10
      Related
      ENSDARP00000067004.3, ENSDART00000067005.5
      Conserved Domains (2) summary
      PRK13357
      Location:36 → 378
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:81 → 375
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      17279966..17297431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009300254.4 → XP_009298529.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X1

      UniProtKB/TrEMBL
      A0A8M3AYQ7
      Conserved Domains (2) summary
      PRK13357
      Location:26 → 368
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:71 → 365
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

    2. XM_005164715.5 → XP_005164772.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X2

      UniProtKB/TrEMBL
      A0A8M2BBX5
      Conserved Domains (2) summary
      PRK13357
      Location:24 → 366
      PRK13357; branched-chain amino acid aminotransferase; Provisional
      cd01557
      Location:69 → 363
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
    Nucleotide Protein Strain
    Heading Accession and Version

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