idh2 isocitrate dehydrogenase (NADP(+)) 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: idh2provided by ZNC
Official Full Name: isocitrate dehydrogenase (NADP(+)) 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-95
See related: Ensembl:ENSDARG00000003795 AllianceGenome:ZFIN:ZDB-GENE-031118-95
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55485; wu:fb33c06; wu:fk31e05; wu:fq43b01
Summary: Predicted to enable NAD binding activity; isocitrate dehydrogenase (NADP+) activity; and magnesium ion binding activity. Predicted to act upstream of or within glyoxylate cycle; isocitrate metabolic process; and tricarboxylic acid cycle. Is expressed in several structures, including blastoderm; brain; digestive system; pectoral fin bud; and renal system. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (26096812..26115561, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (26112294..26131043, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb33c06.x1 (e-PCR)
- UniSTS:190404

fb33c06.x1 (e-PCR)
- UniSTS:190405

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables isocitrate dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables isocitrate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glyoxylate cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isocitrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: isocitrate dehydrogenase [NADP], mitochondrial

Names: isocitrate dehydrogenase 2 (NADP+), mitochondrial

NP_955858.1

EC 1.1.1.42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.