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    pax2b paired box 2b [ Danio rerio (zebrafish) ]

    Gene ID: 60638, updated on 9-Dec-2024

    Summary

    Official Symbol
    pax2bprovided by ZNC
    Official Full Name
    paired box 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-001030-4
    See related
    Ensembl:ENSDARG00000032578 AllianceGenome:ZFIN:ZDB-GENE-001030-4
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pax2.2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within peripheral nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; nervous system; optic vesicle; and spinal cord neural tube. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
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    Genomic context

    See pax2b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (45799982..45876387, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (45637903..45714239, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 9 Neighboring gene uncharacterized LOC137496855 Neighboring gene uncharacterized LOC137496856 Neighboring gene uncharacterized LOC103911951 Neighboring gene uncharacterized LOC137496778

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    General gene information

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    paired box protein Pax-2b
    Names
    paired box gene 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131640.1 → NP_571715.1  paired box protein Pax-2b

      See identical proteins and their annotated locations for NP_571715.1

      Status: PROVISIONAL

      Source sequence(s)
      AF072547
      UniProtKB/Swiss-Prot
      Q90268, Q9PWK8, Q9PWK9, Q9PWL0, Q9PWL1, Q9YGU5, Q9YGU6, Q9YGU7, Q9YGU8, Q9YGU9, Q9YGV0
      UniProtKB/TrEMBL
      O93370
      Related
      ENSDARP00000043209.5, ENSDART00000043210.8
      Conserved Domains (2) summary
      smart00351
      Location:15 → 139
      PAX; Paired Box domain
      pfam12403
      Location:290 → 384
      Pax2_C; Paired-box protein 2 C terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      45799982..45876387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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