shbg sex hormone-binding globulin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: shbgprovided by ZNC
Official Full Name: sex hormone-binding globulinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1324
See related: Ensembl:ENSDARG00000019492 AllianceGenome:ZFIN:ZDB-GENE-030131-1324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: shbgl; wu:fb66h07; wu:fd55b08; zgc:123063
Summary: Enables androgen binding activity and steroid binding activity. Predicted to be located in extracellular region. Is expressed in several structures, including EVL; blood; integument; periderm; and sensory system. Human ortholog(s) of this gene implicated in endometrial cancer and type 2 diabetes mellitus. Orthologous to human SHBG (sex hormone binding globulin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (22510994..22524372, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (22389775..22403153, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHBG controls the flux of sex steroids across fish.
Title: Sex hormone-binding globulin in fish gills is a portal for sex steroids breached by xenobiotics.
characterization of the zebrafish SHBG gene and protein through molecular biological, biochemical, and informatics approaches
Title: Molecular and functional characterization of sex hormone binding globulin in zebrafish.

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General gene information

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Markers

fd55b08.x1 (e-PCR)
- UniSTS:195650

fb67f10 (e-PCR)
- UniSTS:189073

AI545999 (e-PCR)
- UniSTS:206274

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables androgen binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sex hormone-binding globulin

Names: cb991

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007151.3 → NP_001007152.1 sex hormone-binding globulin precursor

See identical proteins and their annotated locations for NP_001007152.1

Status: VALIDATED

Source sequence(s)

AW019651, AY640176, BC108053, EB845503

UniProtKB/TrEMBL

A0A2R8QDI4, F6P172, Q64HD0

Related

ENSDARP00000020485.7, ENSDART00000020942.8

Conserved Domains (1) summary

cl22861
Location:65 → 191

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...