ifi30a IFI30 lysosomal thiol reductase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ifi30aprovided by ZNC
Official Full Name: IFI30 lysosomal thiol reductase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8447
See related: Ensembl:ENSDARG00000056378 AllianceGenome:ZFIN:ZDB-GENE-030131-8447
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GILT; ifi30; wu:fb12b04; zgc:101752
Summary: Enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor and protein-disulfide reductase (NAD(P)H) activity. Acts upstream of or within cell redox homeostasis and hematopoietic stem cell proliferation. Predicted to be located in extracellular region. Predicted to be active in lysosome. Is expressed in several structures, including caudal hematopoietic tissue; digestive system; pleuroperitoneal region; vein; and yolk syncytial layer. Orthologous to human IFI30 (IFI30 lysosomal thiol reductase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (24762567..24767470)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (25106933..25111836)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress.
Title: A connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress.
GILT expression is up-regulated in spleen and kidney after immunization with LPS although it also is constitutively expressed in heart, liver, muscle and intestine, suggesting that GILT may be involved in the immune response to bacterial challenge.
Title: Molecular and biological characterization of interferon-γ-inducible-lysosomal thiol reductase gene in zebrafish (Danio rerio).

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General gene information

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Markers

fb12b04.x1 (e-PCR)
- UniSTS:202858

AI384734 (e-PCR)
- UniSTS:206714

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on a sulfur group of donors	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase (NAD(P)H) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-interferon-inducible lysosomal thiol reductase

Names: LycGILT; gamma-interferon-inducible protein IP-30; interferon, gamma-inducible protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006057.1 → NP_001006057.1 gamma-interferon-inducible lysosomal thiol reductase precursor

See identical proteins and their annotated locations for NP_001006057.1

Status: PROVISIONAL

Source sequence(s)

BC083267

UniProtKB/Swiss-Prot

Q5XJN2

Related

ENSDARP00000073325.3, ENSDART00000078866.5

Conserved Domains (2) summary

pfam03227
Location:63 → 162

GILT; Gamma interferon inducible lysosomal thiol reductase (GILT)

cl02494
Location:31 → 52

SapA; Saposin A-type domain