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    otulinb OTU deubiquitinase with linear linkage specificity b [ Danio rerio (zebrafish) ]

    Gene ID: 100005714, updated on 9-Dec-2024

    Summary

    Official Symbol
    otulinbprovided by ZNC
    Official Full Name
    OTU deubiquitinase with linear linkage specificity bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-627
    See related
    Ensembl:ENSDARG00000079886 AllianceGenome:ZFIN:ZDB-GENE-070912-627
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam105bb; wu:fc69a03; si:dkeyp-106c5.3
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See otulinb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31942391..31952001)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31959157..31969085)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma variable 2 Neighboring gene amphiphysin Neighboring gene ANKH inorganic pyrophosphate transport regulator b Neighboring gene MYC proto-oncogene, bHLH transcription factor b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    ubiquitin thioesterase otulin
    Names
    family with sequence similarity 105, member B
    NP_001159487.1
    XP_005163523.1
    XP_005163524.1
    XP_005163525.1
    XP_005163526.1
    XP_005163527.1
    XP_005163528.1
    XP_009296871.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166015.1NP_001159487.1  ubiquitin thioesterase otulin

      See identical proteins and their annotated locations for NP_001159487.1

      Status: PROVISIONAL

      Source sequence(s)
      CR391940
      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Related
      ENSDARP00000113277.1, ENSDART00000146758.3
      Conserved Domains (1) summary
      pfam16218
      Location:121380
      Peptidase_C101; Peptidase family C101

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      31942391..31952001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163467.5XP_005163524.1  ubiquitin thioesterase otulin isoform X1

      See identical proteins and their annotated locations for XP_005163524.1

      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Conserved Domains (1) summary
      pfam16218
      Location:121380
      Peptidase_C101; Peptidase family C101
    2. XM_005163471.4XP_005163528.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_005163528.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Related
      ENSDART00000133182.3
      Conserved Domains (1) summary
      pfam16218
      Location:61320
      Peptidase_C101; Peptidase family C101
    3. XM_005163468.5XP_005163525.1  ubiquitin thioesterase otulin isoform X1

      See identical proteins and their annotated locations for XP_005163525.1

      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Conserved Domains (1) summary
      pfam16218
      Location:121380
      Peptidase_C101; Peptidase family C101
    4. XM_005163470.5XP_005163527.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_005163527.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Conserved Domains (1) summary
      pfam16218
      Location:61320
      Peptidase_C101; Peptidase family C101
    5. XM_005163466.5XP_005163523.1  ubiquitin thioesterase otulin isoform X1

      See identical proteins and their annotated locations for XP_005163523.1

      UniProtKB/TrEMBL
      A0A8M2BAN8, B0UY67
      Conserved Domains (1) summary
      pfam16218
      Location:121380
      Peptidase_C101; Peptidase family C101
    6. XM_009298596.4XP_009296871.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_009296871.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Conserved Domains (1) summary
      pfam16218
      Location:61320
      Peptidase_C101; Peptidase family C101
    7. XM_005163469.4XP_005163526.1  ubiquitin thioesterase otulin isoform X2

      See identical proteins and their annotated locations for XP_005163526.1

      UniProtKB/TrEMBL
      A0A8M3B0B6
      Related
      ENSDART00000132113.3
      Conserved Domains (1) summary
      pfam16218
      Location:61320
      Peptidase_C101; Peptidase family C101
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