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    prkcda protein kinase C, delta a [ Danio rerio (zebrafish) ]

    Gene ID: 334571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prkcdaprovided by ZNC
    Official Full Name
    protein kinase C, delta aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6503
    See related
    Ensembl:ENSDARG00000009208 AllianceGenome:ZFIN:ZDB-GENE-030131-6503
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prkcd; fb09d10; fv43b11; zgc:56558; wu:fb09d10; wu:fv43b11
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within apoptotic process and protein phosphorylation. Located in immunological synapse. Is expressed in blood; myotome; nervous system; otic vesicle; and somite. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prkcda in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40523370..40544207)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40525834..40546671)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 5b Neighboring gene uncharacterized LOC137495997 Neighboring gene uncharacterized LOC101884206 Neighboring gene DNA-damage inducible protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3. Chen ZL, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30408601
    2. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. Qvit N, et al. J Biol Chem, 2016 Jun 24. PMID 27129213, Free PMC Article
    3. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Binder V, et al. Cell Rep, 2023 May 30. PMID 37209097, Free PMC Article
    4. GAK and PRKCD are positive regulators of PRKN-independent mitophagy. Munson MJ, et al. Nat Commun, 2021 Oct 20. PMID 34671015, Free PMC Article
    5. Differential expression of PKC isoforms in developing zebrafish. Patten SA, et al. Int J Dev Neurosci, 2007 May. PMID 17403595

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase C, delta a
    NP_999873.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214708.1 → NP_999873.1  protein kinase C, delta a

      See identical proteins and their annotated locations for NP_999873.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049327
      UniProtKB/TrEMBL
      A0A8M1PFJ6, Q7ZUC5
      Related
      ENSDARP00000033971.3, ENSDART00000033819.5
      Conserved Domains (3) summary
      cd05620
      Location:361 → 676
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      smart00220
      Location:357 → 611
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:232 → 284
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      40523370..40544207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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