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    ppp4ca protein phosphatase 4, catalytic subunit a [ Danio rerio (zebrafish) ]

    Gene ID: 100003080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppp4caprovided by ZNC
    Official Full Name
    protein phosphatase 4, catalytic subunit aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4433
    See related
    Ensembl:ENSDARG00000070570 AllianceGenome:ZFIN:ZDB-GENE-030131-4433
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pp4c; ppp4c; PP4C-A; gc:56413; zgc:56413; wu:fd05e08
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within angiogenesis; central nervous system development; and determination of ventral identity. Predicted to be located in centrosome. Predicted to be active in cytoplasm and nucleus. Is expressed in blastoderm; brain; and head. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppp4ca in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26236279..26243939, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26105408..26113068, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 3 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 9 Neighboring gene ATPase family AAA domain containing 5a Neighboring gene ArfGAP with dual PH domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability. Kasap M, et al. Schizophr Res, 2018 Dec. PMID 30017463
    2. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos. Jia S, et al. Dev Cell, 2012 May 15. PMID 22595677
    3. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon JM, et al. Hum Mol Genet, 2017 Oct 1. PMID 28934389, Free PMC Article
    4. Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Blaker-Lee A, et al. Dis Model Mech, 2012 Nov. PMID 22566537, Free PMC Article
    5. Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Kalén M, et al. Chem Biol, 2009 Apr 24. PMID 19389629, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos
      Title: Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of ventral identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 4 catalytic subunit A
    Names
    protein phosphatase 4 (formerly X), catalytic subunit a
    NP_001103884.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110414.1 → NP_001103884.1  serine/threonine-protein phosphatase 4 catalytic subunit A

      See identical proteins and their annotated locations for NP_001103884.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154790
      UniProtKB/Swiss-Prot
      A8WGP3, Q7ZWF9
      UniProtKB/TrEMBL
      B7ZVT0
      Related
      ENSDARP00000094516.4, ENSDART00000103741.5
      Conserved Domains (2) summary
      PTZ00239
      Location:10 → 311
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:10 → 294
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      26236279..26243939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8WGP3.1 GenPept UniProtKB/Swiss-Prot:A8WGP3

    Gene LinkOut

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