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    hdac8 histone deacetylase 8 [ Danio rerio (zebrafish) ]

    Gene ID: 406740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hdac8provided by ZNC
    Official Full Name
    histone deacetylase 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2772
    See related
    Ensembl:ENSDARG00000003021 AllianceGenome:ZFIN:ZDB-GENE-040426-2772
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:66196; wu:fd19a02
    Summary
    Predicted to enable histone deacetylase activity and histone decrotonylase activity. Acts upstream of or within central nervous system development and neuron cellular homeostasis. Predicted to be located in chromosome; cytoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including brain; fin bud; gut; muscle; and oocyte. Used to study Cornelia de Lange syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hdac8 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (51656099..51709994, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (51381029..51434924, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4 X-linked Neighboring gene Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 Neighboring gene phosphorylase kinase, alpha 1a (muscle) Neighboring gene liver-expressed antimicrobial peptide 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modeling Cornelia de Lange syndrome in vitro and in vivo reveals a role for cohesin complex in neuronal survival and differentiation. Bottai D, et al. Hum Mol Genet, 2019 Jan 1. PMID 30239720
    2. Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury. Zhuang M, et al. Int J Mol Sci, 2022 Aug 24. PMID 36076983, Free PMC Article
    3. X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition. Volpatti JR, et al. Acta Neuropathol, 2022 Sep. PMID 35844027, Free PMC Article
    4. HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles. Ferrari L, et al. J Cell Physiol, 2019 May. PMID 30246374
    5. HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Spreafico M, et al. Front Cell Dev Biol, 2020. PMID 33015043, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histone Deacetylases Cooperate with NF-kappaB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
      Title: Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury.
    2. We have shown for the first time that HDAC8 is expressed in human and zebrafish skeletal muscles
      Title: HDAC8 regulates canonical Wnt pathway to promote differentiation in skeletal muscles.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone decrotonylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycogen metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase 8
    Names
    HD8
    protein deacetylase HDAC8
    protein decrotonylase HDAC8
    NP_998596.1
    XP_005166564.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213431.1 → NP_998596.1  histone deacetylase 8

      See identical proteins and their annotated locations for NP_998596.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055541
      UniProtKB/Swiss-Prot
      Q7SXM0
      Related
      ENSDARP00000017858.4, ENSDART00000009184.6
      Conserved Domains (1) summary
      cd10000
      Location:17 → 378
      HDAC8; Histone deacetylase 8 (HDAC8)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      51656099..51709994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166507.4 → XP_005166564.1  histone deacetylase 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BE34
      Conserved Domains (1) summary
      cl17011
      Location:1 → 311
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXM0.1 GenPept UniProtKB/Swiss-Prot:Q7SXM0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.