ufd1l ubiquitin recognition factor in ER associated degradation 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ufd1lprovided by ZNC
Official Full Name: ubiquitin recognition factor in ER associated degradation 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-150
See related: Ensembl:ENSDARG00000010051 AllianceGenome:ZFIN:ZDB-GENE-040718-150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc55f04; zgc:92341; wu:fc55f04
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity. Acts upstream of or within cellular response to xenobiotic stimulus and enteric nervous system development. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (4761271..4776395)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (4705004..4720128)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin recognition factor in ER-associated degradation protein 1

Names: ubiquitin fusion degradation 1 like; ubiquitin fusion degradation 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002451.1 → NP_001002451.1 ubiquitin recognition factor in ER-associated degradation protein 1

See identical proteins and their annotated locations for NP_001002451.1

Status: PROVISIONAL

Source sequence(s)

BC076020

UniProtKB/TrEMBL

A8E5G5, Q6DRD5

Related

ENSDARP00000035108.7, ENSDART00000034968.9

Conserved Domains (2) summary

COG5140
Location:1 → 303

UFD1; Ubiquitin fusion-degradation protein [Posttranslational modification, protein turnover, chaperones]

pfam03152
Location:19 → 193

UFD1; Ubiquitin fusion degradation protein UFD1