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    fkbp10b FKBP prolyl isomerase 10b [ Danio rerio (zebrafish) ]

    Gene ID: 324381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkbp10bprovided by ZNC
    Official Full Name
    FKBP prolyl isomerase 10bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3101
    See related
    Ensembl:ENSDARG00000045129 AllianceGenome:ZFIN:ZDB-GENE-030131-3101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fkbp10; wu:fc27c03
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including ball; ectoderm; median fin fold; splanchnocranium; and vasculature. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fkbp10b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (13908418..13956930)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (13848495..13918734)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 11 Neighboring gene uncharacterized LOC137496799 Neighboring gene DBF4B-CDC7 kinase regulatory subunit Neighboring gene kelch-like family member 11 Neighboring gene ATP citrate lyase b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. Westcot SE, et al. PLoS One, 2015. PMID 26110643, Free PMC Article
    2. Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration. Cao Z, et al. Proc Natl Acad Sci U S A, 2021 Jan 12. PMID 33376206, Free PMC Article
    3. Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. Hoffmann S, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Apr-May. PMID 33706013
    4. Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Kujawski S, et al. Dev Cell, 2014 Mar 10. PMID 24561038
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP10
    Names
    FK506 binding protein 10b
    NP_001122138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128666.1 → NP_001122138.1  peptidyl-prolyl cis-trans isomerase FKBP10

      See identical proteins and their annotated locations for NP_001122138.1

      Status: PROVISIONAL

      Source sequence(s)
      BC163794
      UniProtKB/TrEMBL
      B3DKC0, B3DKC8, F6NLV0
      Related
      ENSDARP00000066366.4, ENSDART00000066367.6
      Conserved Domains (2) summary
      pfam00254
      Location:199 → 290
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13499
      Location:537 → 599
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      13908418..13956930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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