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    mcm6 minichromosome maintenance complex component 6 [ Danio rerio (zebrafish) ]

    Gene ID: 566409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcm6provided by ZNC
    Official Full Name
    minichromosome maintenance complex component 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030909-6
    See related
    Ensembl:ENSDARG00000057683 AllianceGenome:ZFIN:ZDB-GENE-030909-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MCM6z; cb800; im:7140796; wu:fb30d05; wu:fc26f09
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded 3'-5' DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication. Predicted to act upstream of or within DNA duplex unwinding and DNA replication. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in central nervous system; proliferative region; and skeletal muscle. Orthologous to human MCM6 (minichromosome maintenance complex component 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mcm6 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (12968146..12985390)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (12733288..12750532)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) receptor 4a Neighboring gene uncharacterized LOC137495832 Neighboring gene si:ch73-71c20.5 Neighboring gene transmembrane BAX inhibitor motif containing 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deregulation of whole-transcriptome gene expression in zebrafish (Danio rerio) after chronic exposure to low doses of imatinib mesylate in a complete life cycle study. Novak M, et al. Chemosphere, 2021 Jan. PMID 33297093
    2. Cohesin facilitates zygotic genome activation in zebrafish. Meier M, et al. Development, 2018 Jan 3. PMID 29158440
    3. Evolutionary diversification of MCM3 genes in Xenopus laevis and Danio rerio. Shinya M, et al. Cell Cycle, 2014. PMID 25485507, Free PMC Article
    4. DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle. Yuan B, et al. Mol Cell Biol, 2016 Dec 1. PMID 27601587, Free PMC Article
    5. The knockdown of maternal glucocorticoid receptor mRNA alters embryo development in zebrafish. Pikulkaew S, et al. Dev Dyn, 2011 Apr. PMID 21360790

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158377

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM6
    Names
    MCM6 minichromosome maintenance deficient 6, mitotin
    zygotic Mcm6 protein
    NP_001076318.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082849.1 → NP_001076318.1  DNA replication licensing factor MCM6

      See identical proteins and their annotated locations for NP_001076318.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133090
      UniProtKB/TrEMBL
      A3KMS0
      Related
      ENSDARP00000022256.8, ENSDART00000013781.9
      Conserved Domains (3) summary
      smart00350
      Location:117 → 655
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:27 → 137
      MCM_N; MCM N-terminal domain
      cl21455
      Location:445 → 532
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      12968146..12985390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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