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    grb10a growth factor receptor-bound protein 10a [ Danio rerio (zebrafish) ]

    Gene ID: 446167, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grb10aprovided by ZNC
    Official Full Name
    growth factor receptor-bound protein 10aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-32
    See related
    Ensembl:ENSDARG00000002013 AllianceGenome:ZFIN:ZDB-GENE-040822-32
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grb10; zgc:91987
    Summary
    Predicted to enable insulin receptor binding activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of Wnt signaling pathway; and negative regulation of insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See grb10a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (23133390..23249839, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (23549067..23665523, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene Ig kappa-b4 chain C region-like Neighboring gene transfer RNA proline (anticodon AGG) Neighboring gene si:dkey-79i2.4 Neighboring gene immunity-related GTPase family, f1 Neighboring gene uncharacterized LOC137488438

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Zhu QS, et al. Nutr Metab (Lond), 2020. PMID 32818036, Free PMC Article
    2. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
    3. Ewing sarcoma ewsa protein regulates chondrogenesis of Meckel's cartilage through modulation of Sox9 in zebrafish. Merkes C, et al. PLoS One, 2015. PMID 25617839, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    growth factor receptor-bound protein 10a
    Names
    growth factor receptor-bound protein 10
    zgc:91987growth factor receptor-bound protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004287.2 → NP_001004287.1  growth factor receptor-bound protein 10a

      See identical proteins and their annotated locations for NP_001004287.1

      Status: VALIDATED

      Source sequence(s)
      BX571825, EH449392
      UniProtKB/TrEMBL
      A0A8N7XJL9, B2GTE0, F6NNM8, Q68EG5
      Related
      ENSDARP00000115883.1, ENSDART00000140665.3
      Conserved Domains (5) summary
      cd10415
      Location:495 → 602
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:295 → 417
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:300 → 407
      PH; PH domain
      pfam08947
      Location:434 → 474
      BPS; BPS (Between PH and SH2)
      cl00155
      Location:175 → 255
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      23133390..23249839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215118.1 → XP_068071219.1  growth factor receptor-bound protein 10a isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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