mul2 mitochondrial E3 ubiquitin protein ligase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mul2provided by ZNC
Official Full Name: mitochondrial E3 ubiquitin protein ligase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050102-5
See related: Ensembl:ENSDARG00000021398 AllianceGenome:ZFIN:ZDB-GENE-050102-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mul1; mul1a; zgc:92166
Summary: Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including mitochondrial fission; positive regulation of canonical NF-kappaB signal transduction; and protein ubiquitination. Predicted to be located in mitochondrial outer membrane and peroxisome. Orthologous to human MUL1 (mitochondrial E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (44960876..44971479, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (45107878..45118481, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Melatonin, added together with MPTP or added once MPTP was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
Title: Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network.

Submit: New GeneRIF Correction

General gene information

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Markers

fd12e12.x1 (e-PCR)
- UniSTS:204132

fc23d08.x1 (e-PCR)
- UniSTS:193148

fc86d12.x1 (e-PCR)
- UniSTS:194684

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within organelle organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitochondrial ubiquitin ligase activator of nfkb 1-A

Names: E3 ubiquitin-protein ligase mul1; E3 ubiquitin-protein ligase mul1-A; RING-type E3 ubiquitin transferase nfkb 1-A; mitochondrial E3 ubiquitin ligase 1; mitochondrial E3 ubiquitin ligase 1a; mitochondrial E3 ubiquitin protein ligase 1a; mitochondrial ubiquitin ligase activator of nfkb 1

NP_001018134.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018124.1 → NP_001018134.1 mitochondrial ubiquitin ligase activator of nfkb 1-A

See identical proteins and their annotated locations for NP_001018134.1

Status: PROVISIONAL

Source sequence(s)

BC088385

UniProtKB/Swiss-Prot

Q5M7X9

Related

ENSDARP00000018598.4, ENSDART00000018818.6

Conserved Domains (2) summary

pfam12483
Location:94 → 248

GIDE; E3 Ubiquitin ligase

pfam13920
Location:289 → 335

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)