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    steap4 STEAP family member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 550429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    steap4provided by ZNC
    Official Full Name
    STEAP family member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070424-244
    See related
    Ensembl:ENSDARG00000055901 AllianceGenome:ZFIN:ZDB-GENE-070424-244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112143; si:dkey-53p21.1
    Summary
    Predicted to enable cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Predicted to be involved in copper ion import. Predicted to act upstream of or within iron ion transport. Predicted to be located in endosome membrane. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP4 (STEAP4 metalloreductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See steap4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (27734871..27749172, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (27800248..27814572, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene NAC alpha domain containing Neighboring gene transforming growth factor beta regulator 4 Neighboring gene zinc finger protein 804B Neighboring gene uncharacterized LOC108179531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Hegedus Z, et al. Mol Immunol, 2009 Sep. PMID 19631987
    2. Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling. Benard EL, et al. Dev Comp Immunol, 2014 Dec. PMID 25086293
    3. Transcriptome analysis of Traf6 function in the innate immune response of zebrafish embryos. Stockhammer OW, et al. Mol Immunol, 2010 Nov-Dec. PMID 20851470
    4. A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery. Veneman WJ, et al. BMC Genomics, 2013 Apr 15. PMID 23586901, Free PMC Article
    5. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cupric reductase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric-chelate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metalloreductase STEAP4
    NP_001017734.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017734.2 → NP_001017734.2  metalloreductase STEAP4

      Status: VALIDATED

      Source sequence(s)
      AL953859
      UniProtKB/TrEMBL
      A0A8M6Z203, F1Q9R5
      Related
      ENSDARP00000118847.1, ENSDART00000145198.2
      Conserved Domains (2) summary
      COG2085
      Location:20 → 201
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:250 → 383
      Ferric_reduct; Ferric reductase like transmembrane component

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      27734871..27749172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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