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    ndc80 NDC80 kinetochore complex component [ Danio rerio (zebrafish) ]

    Gene ID: 445386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ndc80provided by ZNC
    Official Full Name
    NDC80 kinetochore complex componentprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-904
    See related
    Ensembl:ENSDARG00000071694 AllianceGenome:ZFIN:ZDB-GENE-030131-904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    kntc2l; wu:fb52e02; zgc:111801
    Summary
    Predicted to enable kinetochore adaptor activity and microtubule binding activity. Predicted to be involved in mitotic sister chromatid biorientation; mitotic spindle organization; and positive regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to act upstream of or within cell division. Predicted to be located in kinetochore. Predicted to be part of Ndc80 complex. Is expressed in proliferative region. Orthologous to human NDC80 (NDC80 kinetochore complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndc80 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10353366..10365969, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10315523..10328126, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene peptide YYb Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene marker of proliferation Ki-67 Neighboring gene eukaryotic elongation factor 2 kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration. McCurley AT, et al. J Exp Neurosci, 2010 Jul 13. PMID 20740047, Free PMC Article
    2. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinetochore adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within attachment of mitotic spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic sister chromatid biorientation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ndc80 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein NDC80 homolog
    Names
    HEC (highly expressed in cancer)
    NDC80 homolog, kinetochore complex component
    kinetochore protein Hec1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003863.1 → NP_001003863.1  kinetochore protein NDC80 homolog

      See identical proteins and their annotated locations for NP_001003863.1

      Status: PROVISIONAL

      Source sequence(s)
      AY648762
      UniProtKB/Swiss-Prot
      Q502U1, Q6DRJ7
      Related
      ENSDARP00000012236.6, ENSDART00000007335.8
      Conserved Domains (2) summary
      pfam03801
      Location:49 → 203
      Ndc80_HEC; HEC/Ndc80p family
      cl23720
      Location:270 → 377
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      10353366..10365969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DRJ7.1 GenPept UniProtKB/Swiss-Prot:Q6DRJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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