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    prrc2a proline-rich coiled-coil 2A [ Danio rerio (zebrafish) ]

    Gene ID: 394248, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prrc2aprovided by ZNC
    Official Full Name
    proline-rich coiled-coil 2Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010501-4
    See related
    Ensembl:ENSDARG00000031494 AllianceGenome:ZFIN:ZDB-GENE-010501-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bat2; fb96a05; wu:fb96a05; wu:fb96a11
    Summary
    Predicted to be involved in cell differentiation. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PRRC2A (proline rich coiled-coil 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See prrc2a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (26740510..26769912, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (27156287..27185706, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A, member 8 Neighboring gene casein kinase 2, beta polypeptide Neighboring gene si:ch211-222e23.2 Neighboring gene neuraminidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Presence of two tumor necrosis factor (tnf)-α homologs on different chromosomes of zebrafish (Danio rerio) and medaka (Oryzias latipes). Kinoshita S, et al. Mar Genomics, 2014 Feb. PMID 24269726
    2. A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish. Sambrook JG, et al. BMC Genomics, 2005 Nov 4. PMID 16271140, Free PMC Article
    3. Conservation of Mhc class III region synteny between zebrafish and human as determined by radiation hybrid mapping. Sültmann H, et al. J Immunol, 2000 Dec 15. PMID 11120825
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC2A
    Names
    HLA-B-associated transcript 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365423.1 → NP_001352352.1  protein PRRC2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      FP017214, FP085398
      UniProtKB/TrEMBL
      A0A286Y889, A0A8M2BHB2
      Related
      ENSDARP00000143356.1, ENSDART00000174455.2
      Conserved Domains (2) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus
      cl26386
      Location:94 → 287
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    2. NM_201347.3 → NP_958504.2  protein PRRC2A isoform 1

      See identical proteins and their annotated locations for NP_958504.2

      Status: VALIDATED

      Source sequence(s)
      FP017214, FP085398
      UniProtKB/TrEMBL
      A0A8N7XJH9, E7F9N3, Q1LWP7, Q1LXC6
      Related
      ENSDARP00000043775.5, ENSDART00000043776.6
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      26740510..26769912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294206.4 → XP_009292481.1  protein PRRC2A isoform X2

      See identical proteins and their annotated locations for XP_009292481.1

      UniProtKB/TrEMBL
      A0A286Y889, A0A8M2BHB2
      Related
      ENSDARP00000121205.1, ENSDART00000138675.3
      Conserved Domains (2) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus
      cl26386
      Location:94 → 287
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    2. XM_068215056.1 → XP_068071157.1  protein PRRC2A isoform X1

      UniProtKB/TrEMBL
      A0A2R8PXX5, A0A8M2BHC6

    3. XM_005170015.5 → XP_005170072.1  protein PRRC2A isoform X1

      UniProtKB/TrEMBL
      A0A2R8PXX5, A0A8M2BHC6
      Related
      ENSDARP00000145911.1, ENSDART00000193811.1
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 187
      BAT2_N; BAT2 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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