marcksb myristoylated alanine-rich protein kinase C substrate b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: marcksbprovided by ZNC
Official Full Name: myristoylated alanine-rich protein kinase C substrate bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1921
See related: Ensembl:ENSDARG00000008803 AllianceGenome:ZFIN:ZDB-GENE-030131-1921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: macs; marcks; wu:fb55c06; wu:fb92d04; wu:fc19b04; wu:fc44a10; zgc:110235
Summary: Predicted to enable actin filament binding activity. Involved in positive regulation of BMP secretion. Acts upstream of or within several processes, including gastrulation; retina layer formation; and skeletal muscle cell differentiation. Predicted to be located in membrane. Predicted to be active in actin filament bundle; cytoplasm; and plasma membrane. Is expressed in several structures, including nervous system; neural plate; neural rod; neural tube; and neuroectoderm. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (15535515..15539108)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (15527582..15531175)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors revealed that the over-compensation effects of BMP signaling in MZmarcksb was achieved through a sequential up-regulation of MARCKS-family members Marcksa, Marcksl1a and Marcksl1b, and MARCKS-interacting protein Hsp70.3. They concluded that the Marcksb modulates BMP signaling through regulating the secretory pathway of Bmp2b.
Title: Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b.
Marcksb is required for proper gastrulation movements of zebrafish.
Title: Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation.

Submit: New GeneRIF Correction

General gene information

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Markers

fc19b04.x1 (e-PCR)
- UniSTS:203849

AI584867 (e-PCR)
- UniSTS:206220

fe18c03.y1 (e-PCR)
- UniSTS:196278

AI477066 (e-PCR)
- UniSTS:206526

fc44a10 (e-PCR)
- UniSTS:189154

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell morphogenesis involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myristoylated alanine-rich protein kinase C substrate b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015060.2 → NP_001015060.2 myristoylated alanine-rich protein kinase C substrate b

Status: VALIDATED

Source sequence(s)

CU306817, EH503964

UniProtKB/TrEMBL

F6NXD5, H1ZYM6

Related

ENSDARP00000023772.6, ENSDART00000002932.7

Conserved Domains (1) summary

pfam02063
Location:2 → 227

MARCKS; MARCKS family